Lenalidomide

Therapeutic Group

Immunosuppressants

Indication Dosage

Newly Diagnosed Multiple Myeloma In Patients Who Have Undergone Autologous Stem Cell Transplantation: 

  • Adult: 10 Mg Once Daily For 28 Consecutive Days Of Repeated 28-day Cycles; Increased If Tolerated To 15 Mg Once Daily, After 3 Cycles 

Newly Diagnosed Multiple Myeloma In Patients Not Eligible For Transplant (in Combination With Dexamethasone), Multiple Myeloma With Prior Therapy (in Combination With Dexamethasone): 

  • Adult: 25 Mg Once Daily For 21 Consecutive Days Of Repeated 28-day Cycles, For Doses Of Dexamethasone, For Dose Adjustments Due To Side-effects Consult Product Literature 

Newly Diagnosed Multiple Myeloma In Patients Not Eligible For Transplant (in Combination With Melphalan And Prednisone): 

  • Adult: 10 Mg Once Daily For 21 Consecutive Days Of Repeated 28-day Cycles For Up To 9 Cycles, Patients Who Complete 9 Cycles Or Are Intolerant To Combination Therapy Should Continue Treatment With Lenalidomide As Monotherapy. 

Newly Diagnosed Multiple Myeloma In Patients Not Eligible For Transplant (in Combination With Bortezomib And Dexamethasone): 

  • Adult: 25 Mg Once Daily For 14 Consecutive Days Of Repeated 21-day Cycles For Up To 8 Cycles, Followed By 25 Mg Once Daily For 21 Consecutive Days Of Repeated 28-day Cycles (in Combination With Dexamethasone Alone), For Doses Of Bortezomib And Dexamethasone, For Dose Adjustments Due To Side-effects Consult Product Literature 

Myelodysplastic Syndromes: 

  • Adult: 10 Mg Once Daily For 21 Consecutive Days Of Repeated 28-day Cycles. 

Mantle Cell Lymphoma: 

  • Adult: 25 Mg Once Daily For 21 Consecutive Days Of Repeated 28-day Cycles.

Content

  • Cap 10mg /25mg: Lenalidomide 10mg /25mg

Pregnancy

Contraindicated

Stability

  • Immunosuppressants, Thalidomide and Related Analogues

Contra Indications

  • Severe Heart Failure

Precautions

  • Severe Heart Failure

Lactation

  • Discontinue Breast-feeding

Side Effects

  • Anaemia
  • Appetite Decreased
  • Arthralgia
  • Asthenia
  • Atrial Fibrillation
  • Chills
  • Constipation
  • Decreased Leucocytes
  • Dehydration
  • Diarrhoea
  • Dizziness
  • Dyspnoea
  • Electrolyte Imbalance
  • Embolism And Thrombosis
  • Fever
  • Gi Discomfort
  • Gi Disorders
  • Haemorrhage
  • Headache
  • Heart Failure
  • Hyperglycaemia
  • Hypertension
  • Hyperthyroidism
  • Hypotension
  • Hypothyroidism
  • Insomnia
  • Lethargy
  • Muscle Weakness
  • Myocardial Infarction
  • Nausea
  • Neoplasms
  • Nerve Disorders
  • Neutropenia
  • Night Sweats
  • Pain
  • Pancytopenia
  • Paraesthesia
  • Peripheral Oedema
  • Renal Failure
  • Respiratory Disorders
  • Rhinorrhoea
  • Sepsis
  • Skin Reactions
  • Thrombocytopenia
  • Tumour Flare
  • Vertigo
  • Vomiting.
  • Rare: Angioedema
  • Severe Cutaneous Adverse Reactions (scars)
  • Tumour Lysis Syndrome
  • Acquired Haemophilia
  • Hepatic Disorders
  • Hypersensitivity
  • Hypersensitivity Vasculitis
  • Pancreatitis
  • Solid Organ Transplant Rejection