Letrozole

Therapeutic Group

Endocrine Hormone Therapy

Indication Dosage

Letrozole is a medication primarily prescribed to postmenopausal women with hormone receptor-positive breast cancer. It is used as an adjuvant treatment following surgery or radiation to lower the risk of cancer recurrence. Letrozole works by reducing the production of estrogen in the body, which can help slow down or inhibit the growth of cancer cells that rely on estrogen for their development.

First-line Treatment In Postmenopausal Women With Hormone-dependent Advanced Breast Cancer, Adjuvant Treatment Of Oestrogen-receptor-positive Invasive Early Breast Cancer In Postmenopausal Women, Extended Adjuvant Treatment Of Hormone-dependent Invasive Breast Cancer In Postmenopausal Women Who Have Received Standard Adjuvant Tamoxifen Therapy For 5 Years, Neo-adjuvant Treatment In Postmenopausal Women With Localized Hormone-receptor-positive, Human Epidermal Growth Factor-2 Negative Breast Cancer Where Chemotherapy Is Not Suitable And Surgery Not Yet Indicated: 

  • Adult: 2.5 Mg Daily

Content

  • Tab: letrozole 2.5mg.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Non-steroidal Aromatase Inhibitor

Contra Indications

  • Pre-menopausal Women, Very Severe Hepatic Impairment.

Precautions

  • Pre-menopausal Women, Very Severe Hepatic Impairment.

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Anorexia
  • Appetite Increase
  • Arthralgia
  • Bone Fracture
  • Constipation
  • Depression
  • Diarrhoea
  • Dizziness
  • Dry Skin
  • Dyspepsia
  • Fatigue
  • Headache
  • Hot Flushes
  • Hypercholesterolaemia
  • Hypertension
  • Increased Sweating
  • Musculoskeletal Pain
  • Nausea
  • Osteoporosis
  • Peripheral Oedema
  • Rash
  • Vaginal Bleeding
  • Vomiting
  • Weight Changes
  • Anxiety
  • Arthritis
  • Blurred Vision
  • Breast Pain
  • Cardiac Events
  • Cataract
  • Cerebrovascular Events
  • Cough
  • Dysaesthesia
  • Dyspnea
  • Leucopenia
  • Memory Impairment
  • Mucosal Dryness
  • Palpitation
  • Pruritus
  • Pyrexia
  • Stomatitis
  • Tachycardia
  • Thrombophlebitis
  • Tumour
  • Urinary Frequency
  • Urinary-tract Infection
  • Urticaria
  • Hepatitis
  • Toxic Epidermal Necrolysis.
  • Rare Arterial Thrombosis
  • Pulmonary Embolism

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