Metoprolol

Therapeutic Group

Beta Blocking Agent

Indication Dosage

Hypertension: 

Oral: 

  • Adult: Initially 100 Mg Daily, Increased If Necessary To 200 Mg Daily In 1-2 Divided Doses, High Doses Are Rarely Required; Maximum 400 Mg Per Day 

Angina: 

Oral: 

  • Adult: 50-100 Mg 2-3 Times A Day 

Arrhythmias: 

  • Adult: Usual Dose 50 Mg 2-3 Times A Day, Then Increased If Necessary Up To 300 Mg Daily In Divided Doses 

By IV Inj: 

  • Adult: Up To 5 Mg, At A Rate Of 1-2 Mg/minute, Then Up To 5 Mg After 5 Minutes If Required, Total Dose Of 10-15 Mg 

Migraine Prophylaxis: 

Oral: 

  • Adult: 100-200 Mg Daily In Divided Doses 

Hyperthyroidism (adjunct): 

Oral: 

  • Adult: 50 Mg 4 Times A Day 

During Surgery: 

By Slow IV Inj: 

  • Adult: Initially 2-4 Mg, Given At Induction Or To Control Arrhythmias Developing During Anaesthesia, Then 2 Mg, Repeated If Necessary; Maximum 10 Mg Per Course Early Intervention Within 12 Hours Of Infarction: 

By IV Inj: 

  • Adult: Initially 5 Mg Every 2 Minutes, To A Max. Of 15 Mg, Followed By (oral) 50 Mg Every 6 Hours For 48 Hours, To Be Taken 15 Minutes After IV Injection; (oral) Maintenance 200 Mg Daily In Divided Doses 
  • Children: Not Recommended.

Content

  • Tab 25mg /50mg /100mg /200mg: Metoprolol Tartrate 25mg /50mg /100mg /200mg.
  • Inj: Per ml: Metoprolol Tartrate 1mg; 5 ml (5mg) Amp.

Pregnancy

Avoid, Risk Cannot Be Ruled Out.

Stability

  • Beta-blocker

Contra Indications

  • 2nd Or 3rd Degree Av Block (without Pacemaker, Severe Bradycardia, Sick Sinus Syndrome, Un-controlled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.

Precautions

  • 2nd Or 3rd Degree Av Block (without Pacemaker, Severe Bradycardia, Sick Sinus Syndrome, Un-controlled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.

Lactation

  • Caution Advised or Effect Undetermined.

Side Effects

  • Cardiovascular Effects Including Bradycardia
  • Postural Hypotension
  • Increased Av Block
  • Cardiac Arrhythmias
  • Raynaud's Phenomenon
  • Cold Extremities
  • Sexual Dysfunction
  • Gi Upset
  • Sleep And Cns Disturbances
  • Skin Reactions
  • Fatigue
  • Paraesthesia
  • Peripheral Neuropathy
  • Arthralgia
  • Myopathy
  • Altered Blood Sugar Haematology And Lipid Levels. Withdraw If Unexplained Dry Eyes Or Rash.
  • Rare: Heart Failure
  • Dyspnea
  • Bronchospasm

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