Mitomycin

Therapeutic Group

Anti-neoplastics

Indication Dosage

Mitomycin is a medication primarily indicated for the treatment of certain types of cancer, particularly bladder cancer and stomach cancer. It is often used when other forms of chemotherapy have not been effective, and it works by inhibiting the growth of cancer cells. 

Recurrent Superficial Bladder Tumours (bladder Instillation), Bladder Carcinoma: 

By IV Inj: 

  • Adult: 20-40 Mg/dose Every 6-8 Weeks (consult Product Literature) 

Chronic Lymphatic Leukaemia, Chronic Myelogenous Leukaemia, Gastric, Colorectal, Lung, Pancreatic, Liver, Cervix, Endometrium, Head and neck And Breast Cancer: 

By IV Inj: 

  • Adults & Elderly: Monotherapy: 20 Mg/m2 Every 6-8 Week. Combination Therapy: 10 Mg/m2 Every 6-8 Week.

Content

  • Inj 2mg /10mg: mitomycin 2mg /10mg.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Cytotoxic Antibiotic

Contra Indications

  • Thrombocytopenia, Coagulation Disorder, Increased Bleeding Tendency.

Precautions

  • Thrombocytopenia, Coagulation Disorder, Increased Bleeding Tendency.

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Bone Marrow Damage
  • Bone-marrow Suppression
  • Hyperuricaemia
  • Lung Fibrosis
  • Nausea
  • Oral Mucositis
  • Renal Damage
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting
  • Extravasation
  • Bone-marrow Toxicity

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