Naproxen

Therapeutic Group

Anti-inflammatory And Anti-rheumatic Products

Indication Dosage

Pain And Inflammation In Rheumatic Disease: 

  • Adult & Children Above 16 Yrs: 0.5-1 G Daily In 1-2 Divided Doses 

Pain And Inflammation In Musculoskeletal Disorders, Dysmenorrhoea: 

  • Adult & Children Above 16 Yrs: Initially 500 Mg, Then 250 Mg Every 6-8 Hours As Required, Maximum Dose After The First Day 1.25 G Daily 

Acute Gout: 

  • Adult & Children Above 16 Yrs: Initially 750 Mg, Then 250 Mg Every 8 Hours Until the Attack Has Passed 

Migraine: 

  • Adult & Children Above 16 Yrs: 750 Mg At Once Then 250 Mg Or 500 Mg As Needed; Max 1250 Mg Daily. 

Post-operative Pain: 

  • Adult & Children Above 16 Yr: 500 Mg Twice Daily 

Juvenile Idiopathic Arthritis: 

  • Children 6-18 Yrs: 5-7.5 Mg/kg Twice Daily, Max 1 Gm/day.

Content

  • Tab /Cap 275mg (250mg): Naproxen Sodium 275mg Equiv Naproxen 250mg.
  • Tab /Cap 550mg (500mg): Naproxen Sodium 550mg Equiv Naproxen 500mg.
  • Tab /Cap 825 (750mg): Naproxen Sodium 825mg Equiv Naproxen 750mg.

Pregnancy

Contraindicated In Pregnancy

Stability

  • Propionic Acid

Contra Indications

  • Active Gi Bleeding Or Ulceration, History Of Gi Bleeding Or Perforation Related To Previous Nsaid Therapy, History Of Recurrent Gi Haemorrhage Or Ulceration (two Or More Distinct Episodes), Severe Heart Failure, Aspirin/anti-inflammatory Induced Allergy, Hepatic And Renal Failure; Creatinine Clearance <20 Ml/min.

Precautions

  • Active Gi Bleeding Or Ulceration, History Of Gi Bleeding Or Perforation Related To Previous Nsaid Therapy, History Of Recurrent Gi Haemorrhage Or Ulceration (two Or More Distinct Episodes), Severe Heart Failure, Aspirin/anti-inflammatory Induced Allergy, Hepatic And Renal Failure; Creatinine Clearance <20 Ml/min.

Lactation

  • Contraindicated

Side Effects

  • Abdominal Pain
  • Angioedema
  • Blood Disorders
  • Bronchospasm
  • Colitis
  • Crohn's Disease
  • Depression
  • Diarrhoea
  • Dizziness
  • Drowsiness
  • Fluid Retention
  • Gi Bleeding And Ulceration
  • Gi Disturbances
  • Haematuria
  • Headache
  • Hearing Disturbances
  • Hypersensitivity Reactions
  • Nausea
  • Nervousness
  • Photosensitivity
  • Raised Blood Pressure
  • Rashes
  • Renal Failure (especially In Patients With Preexisting Renal Impairment)
  • Tinnitus
  • Vertigo.
  • Rare: Hepatic Damage
  • Interstitial Fibrosis Associated With Nsaids
  • stevens-johnson Syndrome
  • Toxic Epidermal Necrolysis
  • Visual Disturbances
  • Exacerbation Of Symptoms In Asthma
  • Thrombocytopenia
  • Aseptic Meningitis
  • Cns Disturbances.

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