Therapeutic Group

Indication Dosage

Neostigmine is a medication primarily indicated for the treatment of myasthenia gravis, a neuromuscular disorder characterized by muscle weakness and fatigue. It works by inhibiting the breakdown of acetylcholine, a neurotransmitter that is essential for proper muscle function. Neostigmine helps improve muscle strength and endurance in individuals with myasthenia gravis, making it an important therapeutic option for managing the symptoms of this condition.

Treatment Of Myasthenia Gravis: 

By Sc Inj, Or By IM Inj: 

• Adult: 1-2.5 Mg, Dose Repeated At Suitable Intervals Throughout The Day (usual Total Daily Dose 5-20 Mg) 
• Children - Neonate: 150 Mcg/kg Every 6-8 Hr, 30 Minutes Before Feeds, Increased To Max 300 Mcg/kg Every 4 Hr, If Necessary; 
• 1 Month-12 Yrs: 200-500 Mcg Repeated At Suitable Intervals Throughout The Day; 
• 12-18 Yrs: 1-2.5 Mg Repeated At Suitable Intervals Throughout The Day. 

Reversal Of Non-depolarising (competitive) Neuromuscular Blockade: 

By IV Inj: 

• Adult: 2.5 Mg (max. Per Dose 5 Mg), Repeated If Necessary After Or With Glycopyrronium Or Atropine, To Be Given Over 1 Minute 
• Children - Neonate: 50 Mcg/kg. After Or With Glycopyrronium Or Atropine IV Injection Over 1 Minute; A Further Dose Of 25 Mcg/kg May Be Re-quired; 
• 1 Month-12 Yrs: 50 Mcg/kg (max 2.5 Mg) After Or With Glycopyrronium Or Atropine IV Injection Over 1 Minute; A Further Dose Of 25 Mcg/kg May Be Required; 
• 12-18 Yrs: 50 Mcg/kg (max 2.5 Mg) After Or With Glycopyrronium Or Atropine IV Injection Over 1 Minute; A Further Dose Of 25 Mcg/ Kg (max 2.5 Mg) May Be Required. 

Paralytic Ileus, Post-operative Distension: 

• By Sc or IM Inj: Adult: 0.5-2.5 Mg, Repeated If Necessary 

Post-operative Urinary Retention: 

• By Sc or IM Inj: Adult: 0.5- 2.5 Mg, Repeated If Necessary 

Bladder Tony: 

• By Sc Or IM Inj: Adult: Prevention: 0.25 Mg Every 4-6 Hr For 2-3 Days. Treatment: 0.5-1 Mg Every 3 hours for 5 Doses After Bladder Has Emptied.

Content

Pregnancy

Caution Advised Or Avoid

Stability

Contra Indications

Precautions

Lactation

Side Effects