Nitrofurantoin

Therapeutic Group

Urologicals, Anti-infectives

Indication Dosage

Nitrofurantoin is a medication primarily indicated for the treatment and prevention of urinary tract infections (UTIs) caused by susceptible bacteria. It works by inhibiting the growth of bacteria in the urinary tract, thereby helping to alleviate the symptoms of UTIs and prevent their recurrence. 

Acute Uncomplicated Urinary-tract Infections: 

  • Adult: 50 Mg 4 Times A Day For 3-7 Days, To Be Taken With Food 
  • Children 3 Months - 11 Yrs: 750 Micrograms/kg 4 Times A Day For 3-7 Days; 
  • 12-17 Years: 50 Mg 4 Times A Day For 3-7 Days 

Severe Chronic Recurrent Urinary-tract Infections: 

  • Adult: 100 Mg 4 Times A Day For 7 Days, To Be Taken With Food, Reduce Dose Or Discontinue Treatment If Severe Nausea Occurs 
  • Children 12-17 Years: 100 Mg 4 Times A Day For 3-7 Days 

Prophylaxis Of Urinary tract Infection (considered For Recurrent Infection, Significant urinary tract Anomalies, Or Significant Kidney Damage) 

  • Adult: 50-100 Mg Once Daily, Dose To Be Taken At Night 
  • Children 3 Months - 11 Yrs: 1 Mg/kg Once Daily, To Be Taken At Night; 12-17 Yrs: 50-100 Mg Once Daily, To Be Taken At Night 

Genito-urinary Surgical Prophylaxis: 

  • Adult: 100 Mg Twice Daily On the Day Of the Procedure And For 3 Days Afterwards

Content

  • Tab /Cap 100mg: Nitrofurantoin 100mg.

Pregnancy

Avoid At Term, May Produce Neonatal Haemolysis.

Stability

  • Nitrofuran

Contra Indications

  • Acute Porphyrias, G6pd Deficiency, Infants Less Than 3 Months Old

Precautions

  • Acute Porphyrias, G6pd Deficiency, Infants Less Than 3 Months Old

Lactation

  • Avoid; Small Amounts in Milk but May Be Used to Produce Haemolysis

Side Effects

  • Acute Pulmonary Reactions
  • Anaphylaxis
  • Angioedema
  • Anorexia
  • Chronic Pulmonary Reactions (pulmonary Fibrosis Reported; Possible Association With Lupus Erythematosus-like Syndrome)
  • Diarrhoea
  • Hypersensitivity Reactions
  • Nausea
  • Peripheral Neuropathy
  • Pruritus
  • Rash
  • Sialadenitis
  • Urticaria
  • Vomiting.
  • Rare: Agranulocytosis
  • Aplastic Anaemia
  • Arthralgia
  • Benign Intracranial Hypertension
  • Blood Disorders
  • Cholestatic Jaundice
  • Erythema Multiforme
  • Exfoliativedermatitis
  • Hepatitis
  • pancreatitis
  • Thrombocytopenia
  • Transient Alopecia