Paclitaxel
Therapeutic Group
Anti-neoplasticsIndication Dosage
Paclitaxel is a medication primarily used to treat various types of cancer, including breast, lung, ovarian, and pancreatic cancers. It functions as a chemotherapy drug by inhibiting the growth and spread of cancer cells in the body. Paclitaxel is often prescribed in combination with other anticancer medications and is effective in cases where cancer has metastasized or proven resistant to other treatments. It works by disrupting the normal division and growth of cancer cells, ultimately slowing down or preventing their proliferation.
Treatment Of Ovarian Cancer In Combination With Cisplatin:
By IV Inj:
- Adults: 175 Mg/m2 Over 3 Hr Or 135 Mg/m2 Over 24 Hr Every 3 Week.
Treatment Ofmetastatic Ovarian Cancer Where Platinum-containingtherapy Has Failed:
By IV Inj:
- Adults: 135-175 Mg/m2 Over 3 Hr Every 3 Week.
Treatment Of Locally Advanced Or Metastatic Breast Cancer (in Combination Or Alone), Adjuvant Treatment Of Node-positive Breast Cancer Following Treatment With Anthracycline And Cyclophosphamid:
By IV Inj:
- Adults: 175 Mg/m2 Over 3 Hr Every 3 Week.
Treatment Of Non-small Cell Lung Cancer (in Combination With Cisplatin) When Surgery Or Radiotherapy Not Appropriate:
By IV Inj:
- Adults: 135 Mg/m2 Over 24 Hr Every 3 Week.
Treatment Of Advanced Aids-related Kaposi'ssarcoma Where Liposomal Anthracycline Therapy Has Failed, First-linetreatment Of Metastatic Adenocarcinoma Of Thepancreas (in Combination With Gemcitabine):
By IV Inj:
- Adults: 135 Mg/m2 Over 3 Hr Every 3 weeks or 100 Mg/m2 Over 3 Hr Every 2 Week.
- Children: Not Applicable.
Content
- Inj 30mg /100mg /150mg /260mg /300mg: Per ml: Paclitaxel 6mg; Vial.
Pregnancy
Contraindication In Pregnancy
Stability
- Taxane
Contra Indications
- Acute Porphyrias, Neutrophils Less Than 1.5x109 Per Litre, Severe Hepatic Impairment.
Precautions
- Acute Porphyrias, Neutrophils Less Than 1.5x109 Per Litre, Severe Hepatic Impairment.
Lactation
- Contraindicated. Discontinue Breast-feeding
Side Effects
- Arrhythmia
- Arthralgia
- Febrileneutropenia
- Gi Disorders
- Myalgia
- Peripheral Neuropathy
- Sensory Neuropathy
- Tachycardia
- Alopecia
- Hypotension
- Bone Marrow Suppression
- Bradycardia
- Cardiac Conduction Defects
- Extravasation
- Hypersensitivity Reactions
- Hyperuricaemia
- Muscle Pain
- Myelosuppression
- Nausea
- Neutropenia
- Oral Mucositis
- Pneumonitis
- Stevens-johnson Syndrome
- Thromboembolism
- Toxic Epidermal Necrolysis
- Tumourlysis Syndrome
- Vomiting.
- Rare: Bradycardia
- Cardiac Arrest
- Congestive Heart Failure
- Left Ventricular Dysfunction