Pamidronate Disodium
Therapeutic Group
Drugs For Treatment Of Bone DiseasesIndication Dosage
Hypercalcemia Of Malignancy:
By IV Infusion:
- Adult: 15-60 Mg, To Be Given Via Cannula In A Relatively Large Vein As A Single Infusion Or In Divided Doses Over 2-4 Days, Dose Adjusted According To Serum Calcium Concentration; Maximum 90 Mg Per Course.
Osteolytic Lesions And Bone Pain In Bone Metastases Associated With Breast Cancer Or Multiple Myeloma:
By IV Infusion:
- Adult: 90 Mg Every 4 Weeks, To Be Administered Via Cannula In A Relatively Large Vein, Dose May Alternatively Be Administered Every 3 Weeks, To Coincide With Chemotherapy In Breast Cancer
Paget's Disease Of Bone:
By IV Infusion:
- Adult: 30 Mg Every Week For A 6 Week Course (total Dose180 Mg), Alternatively Initially 30 Mg Once Weekly For 1 Week, Then Increased To 60 Mg Every 2 Weeks (max. Per Dose 60 Mg) For A 6 Week Course (total Dose 210 Mg), To Be Administered Via Cannula In A Relatively Large Vein, Course May Be Repeated Every 6 Months; Maximum 360 Mg Per Course
Capsule:
- Adults: 200 Mg Daily.
- Children: Not Recommended.
Content
- Inj 3mg: Per ml, Pamidronate Disodium 3mg; 5 ml (15mg) Vial; 10 ml (30mg) Vial.
- Inj 6mg: Per ml: Pamidronate Disodium 6mg: 10 ml (60mg) Vial.
- Inj 15mg: Per ml: Pamidronate Disodium 15mg.
Pregnancy
Positive Evidence Of Risk, Use Only When No Safer Alternative Exists For A Serious Problem.
Stability
- Diphosphonate
Contra Indications
- None Known
Precautions
- None Known
Lactation
- Caution Advised
Side Effects
- Abdominal Pain
- Anaemia
- Anorexia
- Arthralgia
- Bone Pain
- Constipation
- Diarrhoea
- Drowsiness
- Fever
- Headache
- Hypertension
- Hypomagnesaemia
- Hypophosphataemia
- Influenza- Like Symptoms
- Insomnia
- Myalgia
- Nausea
- Paraesthesia
- Rash
- Symptomatic Hypocalcaemia
- Tetany
- Thrombocytopenia
- Vomiting
- Mild Transient Pyrexia
- Transient Lymphocytopenia
- Infusion Site Reactions
- Rarely
- Leucopenia
- Anaemia
- Other Biochemical Disturbances.