Paracetamol

Therapeutic Group

Other Analgesics And Anti-pyretics

Indication Dosage

Mild To Moderate Pain, Pyrexia: 

Oral: 

  • Adult: 0.5-1 G Every 4-6 Hours; Maximum 4 G Per Day 

By IV Infusion: 

  • Adult (body-weight Up To 50 Kg): 15 Mg/kg Every 4-6 Hours, Dose To Be Administered Over 15 Minutes; Maximum 60 Mg/kg Per Day; (body-weight 50 Kg And Above): 1 Gm Every 4-6 Hours, Dose To Be Administered Over 15 Minutes; Maximum 4 G Per Day 

By Rectum: 

  • Adult: 0.5-1 G Every 4-6 Hours; Maximum 4 Gm Per Day 

Mild To Moderate Pain In Patients With Risk Factors For Hepatotoxicity, Pyrexia In Patients With Risk Factors Forhepatotoxicity: 

By IV Infusion: 

  • Adult (body-weight Up To 50 Kg): 15 Mg/kg Every 4-6 Hours, Dose To Be Administered Over 15 Minutes; Maximum 60 Mg/kg Per Day; (body-weight 50 Kg And Above): 1 Gm Every 4-6 Hours, Dose To Be Administered Over 15 Minutes; Maximum 3 G Per Day 

Pain, Pyrexia With Discomfort: 

Oral: 

  • Children 3-5 Months: 60 Mg Every 4-6 Hours; 
  • 6 Months-1 Yr: 120 Mg Every 4-6 Hours; 
  • 2-3 Yrs: 180 Mg Every 4-6 Hours; 
  • 4-5 Yrs: 240 Mg Every 4-6 Hours; 
  • 6-7 Yrs: 240-250 Mg Every 4-6 Hours; 
  • 8-9 Yrs: 360-375 Mg Every 4-6 Hours; Maximum 4 Doses Per Day;
  • 10-11 Yrs: 480-500 Mg Every 4-6 Hours; 
  • 12-15 Yrs: 480-750 Mg Every 4-6 Hours; 
  • 16-17 Yrs: 0.5-1 G Every 4-6 Hours. Maximum 4 Doses Per Day 

By Rectum: 

  • Children 3-11 Months: 60-125 Mg Every 4-6 Hours As Required; Maximum 4 Doses Per Day; 
  • 1-4 Yrs: 125-250 Mg Every 4-6 Hours As Required; Maximum 4 Doses Per Day; 
  • 5-11 Yrs: 250-500 Mg Every 4-6 Hours As Required; Maximum 4 Doses Per Day; 
  • 12-17 Yrs: 500 Mg Every 4-6 Hours 

By IV Infusion: 

  • Neonate: 10 Mg/kg Every 4-6 Hr, Max 30 Mg/ Kg/day; Child weight below 10 Kg: 10 Mg/kg Every 4-6 Hr, Max 30 Mg/kg/day; 
  • Child Body-weight 10-50 Kg: 15 Mg/kg Every 4-6 Hr, Max 60 Mg/kg/day; Child Body-weight Over 50 Kg: 1 Gm Every 4-6 Hr, Max 4 Gm Daily. 

Post-immunisation Pyrexia In Infants 

Oral: 

  • Child 2-3 Months: 60 Mg For 1 Dose, Then 60 Mg After 4-6 Hours If Required; 4 Months: 60 Mg For 1 Dose, Then 60 Mg After 4-6 Hours; Maximum 4 Doses Per Day 

Postoperative Pain: 

  • Adult: 1 Gm Every 4-6 Hr, Max 4 Doses/ Day 
  • Children 1-3 Months: 30 Mg/kg As A Single Dose Then 15-20 Mg/kg Every 4-6 Hr, Max 75 Mg/kg/day In Divided Doses;
  • 3 Months-6 Yr: 30-40 Mg/kg As A Single Dose Then 15-20 Mg/kg Every 4-6 Hr, Max 75 Mg/kg Daily In Divided Doses; 
  • 6-12 Yr: 30-40 Mg/kg, (max 1 Gm) As A Single Dose Then 15-20 Mg/kg Every 4-6 Hr, Max 75 Mg/kg (max 4 G) Daily In Divided Doses;
  • 12-18 Yr: 1 Gm Every 4-6 Hr, Max 4 Doses/ Day.

Content

  • Drop 60mg: Per 5 ml: Paracetamol 60mg.
  • Drop 80 /100mg: Per ml: Paracetamol 80 /100mg.
  • Elixir /Liqd /susp 120mg /150mg /160mg: Per 5 ml: Paracetamol 120mg /150mg /160mg.

Pregnancy

No Evidence Of Risk

Stability

  • Non Opioid Analgesic

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Caution Advised

Side Effects

  • Rare: Skin Reactions
  • Blood Disorders
  • Hepatoxicity (high Dose)
  • Stevens-Johnson Syndrome
  • Toxicepidermal Necrolysis
  • Acute Generalized Exanthematous Pustulosis
  • Malaise
  • Leucopenia
  • Neutropenia
  • Thrombocytopenia. With Intravenous Use:
  • Rare: Flushing
  • Tachycardia
  • Hypotension

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