Perindopril

Therapeutic Group

Ace Inhibitor

Indication Dosage

Hypertension: 

  • Adult: Initially 5 Mg Perindopril (as Arginine) Once Daily For 1 Month, Dose To Be Taken In The Morning, Then, Adjusted According To Response; Maximum 10 Mg Per Day. Alternatively; Initially 4 Mg Perindopril (as Terbutylamine) Once Daily For 1 Month, the Dose To Be Taken In The Morning, Then, Adjusted According To Response; Maximum of 8 Mg Per Day 
  • Elderly: Initially 2.5 Mg Perindopril (as Arginine) Once Daily For 1 Month, Dose To Be Taken In The Morning, Then, Adjusted According To Response; Maximum 10 Mg Per Day. Alternatively; Initially 2 Mg Perindopril (as Terbutylamine)once Daily For 1 Month, Dose To Be Taken In The Morning, Then, Adjusted According To a Response; Maximum of 8 Mg Per Day 

Hypertension, If Used In Addition To Diuretic, Or In Cardiac Decompensation Or Volume Depletion: 

  • Adult: Initially 2.5 Mg Perindopril (as Arginine) Once Daily For 1 Month, Dose Tobe Taken In The Morning, Then, Adjusted According To Response; Maximum 10 Mg Per Day. Alternatively; Initially 2 Mg Perindopril (as Terbutylamine)once Daily For 1 Month, Dose To Be Taken In The Morning, Then, Adjusted According To a Response; Maximum of 8 Mg Per Day 

Symptomatic Heart Failure (adjunct): 

  • Adult: Initially 2.5 Mg Perindopril (as Arginine) Once Daily For 2 Weeks, Then Increased If Tolerated To 5 Mg Once Daily, Dose To Be Taken In The Morning. Alternatively; Initially 2 Mg Perindopril (as Terbutylamine) Once Daily For At Least 2 Weeks, the Dose To Be Taken In The Morning, Then Increased If Tolerated To 4 Mg Once Daily 

Prophylaxis Of Cardiac Events Following Myocardial Infarction Or Revascularisation In Stable Coronary Artery Disease: 

  • Adult: Initially 5 Mg Perindopril (as Arginine) Once Daily For 2 Weeks, Then Increased If Tolerated To 10 Mg Once Daily, Dose To Be Taken In The Morning. Alternatively; Initially 4 Mg Perindopril (as Terbutylamine)once Daily For 2 Weeks, the Dose To Be Taken In The Morning, Then Increased If Tolerated To 8 Mg Once Daily 
  • Elderly: Initially 2.5 Mg Perindopril (as Arginine) Once Daily For 1 Week, Then Increased If Tolerated To 5 Mg Once Daily For 1 Week, Then Increased If Tolerated To 10 Mg Once Daily, Dose To Be Taken In The Morning. Alternatively; Initially 2 Mg Perindopril (as Terbutylamine) Once Daily For 1 Week, Then Increased If Tolerated To 4 Mg Once Daily For 1 Week, Then Increased If Tolerated To 8 Mg Once Daily 
  • Children: Not Recommended.

Content

  • Tab 2mg /4mg /8mg (as Terbutylamine): Perindopril 2mg /4mg /8mg (as Terbutylamine).
  • Tab 5mg /10mg (as Arginine): Perindopril 5mg /10mg (as Arginine).

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Angiotensin-converting Enzyme (ace) Inhibitors

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Not Recommended.

Side Effects

  • Asthenia
  • Mood Disturbance
  • Sleep Disturbance
  • Flushing
  • Angioneurotic Oedema
  • Taste Disturbance
  • Nausea
  • Abdominal Pain
  • Fatigue
  • Headache
  • Low Haemoglobin
  • Red Cells And Platelets Counts
  • Reversible Increase In Blood Urea And Creatinine
  • Proteinuria
  • Skin Rashes