Pioglitazone And Metformin

Therapeutic Group

Blood Glucose Lowering Drugs, Excluding Insulin

Indication Dosage

Type 2 Diabetes Not Controlled By Metformin Alone, Particularly In Obese: 

  • Adult: 1 Tablet Twice Daily, Titration With The Individual Components (pioglitazone And Metformin) Desirable Before Initiation 
  • Children: Not Recommended.

Content

  • Tab 15 /500mg: Pioglitazone 15mg, Metformin500mg.
  • Tab 15 /850mg: Pioglitazone 15mg, Metformin 850mg.

Pregnancy

Contraindicated Or Not Recommended

Stability

  • Biguanide
  • Thiazolidinedione

Contra Indications

  • History Of Heart Failure, Previous Or Active Bladder Cancer, Severe Infection, Shock, Trauma, Uninvestigated Haematuria, Dialysis, Diabetic Ketoacidosis, Pregnancy And Lactation.

Precautions

  • History Of Heart Failure, Previous Or Active Bladder Cancer, Severe Infection, Shock, Trauma, Uninvestigated Haematuria, Dialysis, Diabetic Ketoacidosis, Pregnancy And Lactation.

Lactation

  • Contraindicated or Not Recommended.

Side Effects

  • Gi Disturbances
  • Anaemia
  • Arthralgia
  • Dizziness
  • Haematuria
  • Headache
  • Hypoaesthesia
  • Impotence
  • Oedema
  • Vertigo
  • Visual Disturbances
  • Weight Gain
  • Altered Blood Lipids
  • Bladder Cancer
  • Fatigue
  • Hypoglycaemia
  • Insomnia
  • Proteinuria
  • Sweating
  • Rare; Liver Dysfunction.

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