Pyrazinamide
Therapeutic Group
Anti-mycobacterials (Anti-tuberculosis)Indication Dosage
Tuberculosis, In Combination With Other Drugs (standard Unsupervised 6-month Treatment):
- Adult: 1.5-2 G Once Daily For2 Months (initial Phase)
- Children: 35 Mg/kg Once Daily For 2 Months (initial Phase); Maximum 1.5 G Per Day
Tuberculosis, In Combination With Other Drugs (intermittent Supervised 6-month Treatment):
- Adult: 2-2.5 G 3 Times A Week For 2 Months (initial Phase)
- Children: 50 Mg/kg 3 Times A Week (max. Per Dose 2 G 3 Times A Week) For 2 Months (initial Phase)
Content
- Tab: Pyrazinamide 500mg.
- Syp: Per 5 ml: Pyrazinamide 250mg.
Pregnancy
Caution Advised, Use Only If Potential Benefit Outweighs Risk
Stability
- Nicotinic Acid Derivative
Contra Indications
- Liver Disease.
Precautions
- Liver Disease.
Lactation
- Caution Advised
Side Effects
- Anorexia
- Arthralgia
- Dysuria
- Fever
- Flushing (in Adults)
- Hepatomegaly
- Hepatotoxicity
- Jaundice
- Liver Failure
- Nausea
- Photosensitivity
- Rash
- Sideroblastic Anaemia
- Splenomegaly
- Thrombocytopenia
- Vomiting