Isoniazid

Therapeutic Group

Anti-mycobacterials (Anti-tuberculosis)

Indication Dosage

Tuberculosis, In Combination With Other Drugs (standard Unsupervised 6-month Treatment): 

  • Adult: 300 Mg Daily For 6 Months (initial And Continuation Phases) 
  • Children: 10 Mg/kg Once Daily (max. Per Dose 300 Mg) For 6 Months (initial And Continuation Phases) 

Tuberculosis, In Combination With Other Drugs (intermittent Supervised 6-month Treatment): 

  • Adult: 15 Mg/kg 3 Times A Week (max. Per Dose 900 Mg) For 6 Months (initial And Continuation Phases) 
  • Children: 15 Mg/kg 3 Times A Week (max. Per Dose 900 Mg) For 6 Months (initial And Continuation Phases) 

Prevention Of Tuberculosis In Susceptible Close Contacts or those who Have Become Tuberculin Positive: 

  • Adult & Children Above 12 Yrs: 300 Mg Daily For 6 Months, Alternatively 300 Mgdaily For 3 Months, To Be Taken In Combination Withrifampicin 
  • Children 1 Month-11 Yrs: 10 Mg/kg Daily (max. Per Dose 300 Mg) For 6 Months, Alternatively 10 Mg/kg Daily (max. Per Dose 300 Mg) For 3 Months, To Be Taken In combination With Rifampicin

Content

  • Tab 50mg /100mg /300mg: Isoniazid 100mg /300mg.
  • Syp: Per 5 ml: Isoniazid 50mg.

Pregnancy

Caution Advised, Use Only If Potential Benefit Outweighs Risk

Stability

  • Isonicotinic Acid Derivative

Contra Indications

  • Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Iso-niazid.

Precautions

  • Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Iso-niazid.

Lactation

  • Caution Advised

Side Effects

  • Peripheral Neuropathy
  • Agranulocytosis
  • Aplastic Anaemia
  • Blood Disorders
  • Constipation
  • Convulsions
  • Difficulty With Micturition
  • Dry Mouth
  • Fever
  • Gynaecomastia
  • Haemolytic Anaemia
  • Hearing Loss (in Patients With End-stage Renal Impairment)
  • Hyperglycaemia
  • Hyperreflexia
  • Hypersensitivity Reactions
  • Interstitial Pneumonitis
  • Nausea
  • Optic Neuritis
  • Pancreatitis
  • Pellagra
  • Peripheral Neuritis With High Doses
  • Purpura
  • Stevens-johnson Syndrome
  • Systemic Lupus Erythematosus-like Syndrome
  • Tinnitus (in Patients With End-stage Renal Impairment)
  • vertigo
  • Vomiting.
  • Rare: Hepatitis
  • Psychotic Episodes