Tuberculosis, In Combination With Other Drugs (standard Unsupervised 6-month Treatment):
Adult: 300 Mg Daily For 6 Months (initial And Continuation Phases)
Children: 10 Mg/kg Once Daily (max. Per Dose 300 Mg) For 6 Months (initial And Continuation Phases)
Tuberculosis, In Combination With Other Drugs (intermittent Supervised 6-month Treatment):
Adult: 15 Mg/kg 3 Times A Week (max. Per Dose 900 Mg) For 6 Months (initial And Continuation Phases)
Children: 15 Mg/kg 3 Times A Week (max. Per Dose 900 Mg) For 6 Months (initial And Continuation Phases)
Prevention Of Tuberculosis In Susceptible Close Contacts or those who Have Become Tuberculin Positive:
Adult & Children Above 12 Yrs: 300 Mg Daily For 6 Months, Alternatively 300 Mgdaily For 3 Months, To Be Taken In Combination Withrifampicin
Children 1 Month-11 Yrs: 10 Mg/kg Daily (max. Per Dose 300 Mg) For 6 Months, Alternatively 10 Mg/kg Daily (max. Per Dose 300 Mg) For 3 Months, To Be Taken In combination With Rifampicin
Content
Tab 50mg /100mg /300mg: Isoniazid 100mg /300mg.
Syp: Per 5 ml: Isoniazid 50mg.
Pregnancy
Caution Advised, Use Only If Potential Benefit Outweighs Risk
Stability
Isonicotinic Acid Derivative
Contra Indications
Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Iso-niazid.
Precautions
Patients With Previous Isoniazid Associated Hepatic Injury Or Other Severe Adverse Reactions With Iso-niazid.
Lactation
Caution Advised
Side Effects
Peripheral Neuropathy
Agranulocytosis
Aplastic Anaemia
Blood Disorders
Constipation
Convulsions
Difficulty With Micturition
Dry Mouth
Fever
Gynaecomastia
Haemolytic Anaemia
Hearing Loss (in Patients With End-stage Renal Impairment)
Hyperglycaemia
Hyperreflexia
Hypersensitivity Reactions
Interstitial Pneumonitis
Nausea
Optic Neuritis
Pancreatitis
Pellagra
Peripheral Neuritis With High Doses
Purpura
Stevens-johnson Syndrome
Systemic Lupus Erythematosus-like Syndrome
Tinnitus (in Patients With End-stage Renal Impairment)