Sodium Nitroprusside

Therapeutic Group

Cardiac Therapy

Indication Dosage

Sodium Nitroprusside is a medication primarily indicated for the immediate reduction of blood pressure in cases of severe hypertension, hypertensive crises, or during certain surgical procedures where controlled hypotension is required. It acts as a potent vasodilator, relaxing blood vessels and promoting increased blood flow, effectively lowering blood pressure levels.

Hypertensive Emergencies: 

By IV Infusion: 

  • Adult: Initially 0.5-1.5 Mcg/kg/minute, Adjusted In Steps Of 500 Nanograms/kg/minute Every 5 Minutes, Usual Dose 0.5-8 Mcg/kg/minute, Use Lower Doses If Already Receiving Other Anti-hypertensives, Stop If Response Unsatisfactory With Max. Dose In 10 Minutes, a Lower Initial Dose Of 300 Nanograms/kg/minute was used. 

Maintenance Of Blood Pressure At 30-40% Lower Than Pretreatment Diastolic Blood Pressure: 

By IV Infusion: 

  • Adult: 20-400 Mcg/minute, Use Lower Doses For Patients Being Treated With Other Anti-hypertensives 

Controlled Hypotension In Anaesthesia During Surgery: 

By IV Infusion: 

  • Adult: Up To 1.5 Mcg/kg/minute 

Acute Or Chronic Heart Failure: 

By IV Infusion: 

  • Adult: Initially 10-15 Mcg/minute, Increased Every 5-10 Minutes As Necessary; Usual Dose10-200 Mcg/minute Normally For Max. 3 Days

Content

  • Inj: Per ml: Sodium Nitroprusside 25mg; 2 ml (50mg).

Pregnancy

Caution Advised

Stability

  • Antihypertensive: Vasodilator

Contra Indications

  • Severe Vitamin B12 Deficiency, Leber's Optic Atrophy, Compensatory Hypertension.

Precautions

  • Severe Vitamin B12 Deficiency, Leber's Optic Atrophy, Compensatory Hypertension.

Lactation

  • Caution Advised

Side Effects

  • Abdominal Pain
  • Acute Transient Phlebitis
  • Anxiety
  • Dizziness
  • Headache
  • Nausea
  • Palpitation
  • Perspiration
  • Reduced Platelet Count
  • Retching
  • Retrosternal Discomfort

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