Tinidazole

Therapeutic Group

Agents Against Amoebiasis and Protozoal Diseases

Indication Dosage

Tinidazole is a medication primarily indicated for the treatment of various infections caused by susceptible microorganisms, including certain types of protozoa and anaerobic bacteria. It is commonly prescribed to address conditions such as trichomoniasis, giardiasis, amebiasis, and certain bacterial infections in the gastrointestinal tract, genital area, and other parts of the body. Tinidazole works by disrupting the DNA structure of these pathogens, effectively eradicating the infection and providing relief from associated symptoms.

Anaerobic Infections: 

  • Adult: Initially 2 G, Followed By 1 G Daily Usually For 5-6 Days, Alternatively 500 Mg Twice Daily Usually For 5-6 Days 

Bacterial Vaginosis, Acute Ulcerative Gingivitis: 

  • Adult: 2 G For 1 Single Dose 

Abdominal Surgery Prophylaxis: 

  • Adult: 2 G For 1 Single Dose, To Be Administered Approximately 12 Hours Before Surgery 

Intestinal Amoebiasis: 

  • Adult: 2 G Once Daily For 2-3 Days 
  • Children 1 Month-11 Yrs: 50-60 Mg/kg Once Daily (max. Per Dose 2 G) For 3 Days; 
  • 12-17 Years: 2 G Once Daily For 2-3 Days 

Amoebic Involvement Of Liver: 

  • Adult: 1.5-2 G Once Daily For 3-6 Days 
  • Children 1 Month-11 Yrs: 50-60 Mg/kg Once Daily (max. Per Dose 2 G) For 5 Days; 
  • 12-17 Yrs: 1.5-2 G Once Daily For 3-6 Days 

Urogenital Trichomoniasis, Giardiasis: 

  • Adult: 2 G For 1 Single Dose 
  • Children 1 Month-11 Yrs: 50-75 Mg/kg (max. Per Dose 2 G) For 1 Single Dose, Dose May Be Repeated Once If Necessary; 
  • 12-17 Yrs: 2 G For 1 Single Dose, Dose May Be Repeated Once If Necessary 

Helicobacter Pylori Eradication: 

  • Adult: (consult Local Protocol)

Content

  • Tab 150mg /300mg /500mg /1gm: Tinidazole 150mg /300mg /500mg /1gm.

Pregnancy

Contraindicated

Stability

  • Nitroimidazole

Contra Indications

  • Blood Dyscrasias, Neurological Disorders.

Precautions

  • Blood Dyscrasias, Neurological Disorders.

Lactation

  • Contraindicated

Side Effects

  • Anorexia
  • Furred Tongue
  • Gi Disturbances
  • Nausea
  • Oral Mucositis
  • Taste Disturbances
  • Vomiting
  • Urticaria
  • Angioedema
  • Cns Disturbances
  • Dark Urine
  • Neuropathy And Leucopenia On Long Term Therapy.