Tobramycin
Therapeutic Group
Aminoglycoside Anti-bacterialsIndication Dosage
Bone & Joint Infections, Lower Respiratory Tract Infections, Septicaemia, Meningitis And Other CNS infections, Biliarytract Infection, Acute Pyelonephritis Or Prostatitis, Pneumonia In Hospital Patients:
By IM Inj, Or By Slow IV Inj, Or By IV Infusion:
- Adult: 3 Mg/kg Daily In 3 Divided Doses; Increased If Necessary Up To 5 Mg/kg Daily In 3-4 Divided Doses, Increased Dose Used In Severe Infection; Dose To Be Reduced Back To 3 Mg/kg Daily As Soon As Clinically Indicated
Urinary-tract Infection:
By IM Inj:
- Adult: 2-3 Mg/kg For 1 Dose
Content
- In] 10mg /20mg /40mg /80mg: Tobramycin (as Sulphate) 10mg /20mg /40mg /80mg; Amp /vial.
Pregnancy
Consult with Doctor Or Caution Advised
Stability
- Aminoglycoside Antibiotics
Contra Indications
- None Known
Precautions
- None Known
Lactation
- Consult with Doctor Or Caution Advised
Side Effects
- Auditory Damage
- Impaired Neuromuscular Transmission
- Irreversible Ototoxicity
- Nephrotoxicity
- Transient Myasthenic Syndrome In Patients With Normal Neuromuscular Function With Large Doses Given During Surgery
- Vestibular Damage.
- Rare: Antibiotic-associated Colitis
- Electrolyte Disturbances
- Hypocalcaemia
- Hypokalaemia
- Hypomagnesaemia On Prolonged Therapy
- Nausea
- Peripheral Neuropathy
- Stomatitis
- Vomiting
- Blood Disorders
- Cns Effects
- Convulsions
- Encephalopathy
- Rash