Tocilizumab

Therapeutic Group

Immunosuppressants

Indication Dosage

Moderate To Severe Active Rheumatoid Arthritis Alone Or With Methotrexate If Other Dmard Or Tnf Inhibitor Has Been Inadequate, Or In Patients Intolerant Of These Drugs: 

By IV Infusion: 

  • Adult: 8 Mg/kg Every 4 Wks (max. Per Dose 800 Mg), For Dose Adjustments In Patients With Liver Enzyme Abnormalities, Or Low Absolute Neutrophil Or Platelet Count, Consult Product Literature

Content

  • Inf: 4ml, 10 ml, 20 ml: Per ml: Tocilizumab 20mg

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Immunosuppressants
  • Interleukin Inhibitors

Contra Indications

  • Severe Active Infection, Absolute Neutrophil Count Less Than 2x109/litre

Precautions

  • Severe Active Infection, Absolute Neutrophil Count Less Than 2x109/litre

Lactation

  • Avoid During Treatment and for up to 20 Weeks After Discontinuing Treatment

Side Effects

  • Headache
  • Dizziness
  • Abdominal Pain
  • Antibody Formation
  • Gastritis
  • Gastric Ulcer
  • Gi Perforation
  • Hypercholesterolaemia
  • Hypersensitivity
  • Hypertension
  • Infection
  • Leucopenia
  • Mouth Ulceration
  • Neutropenia
  • Peripheral Oedema
  • Pruritus
  • Raised Hepatic Transaminases
  • Rash
  • Upper Respiratory-tract Infection
  • Anaphylaxis.
  • Rare: Hypertriglyceridaemia
  • Hypothyroidism
  • Infusion Related Reactions
  • Nephrolithiasis
  • Thrombocytopenia

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