Topiramate

Therapeutic Group

Anti-epileptics

Indication Dosage

Topiramate is a medication that is used to help with different health conditions:

  • Seizures: It's used to prevent and control seizures in people with epilepsy.
  • Migraines: It can reduce the frequency and severity of migraine headaches.
  • Weight Loss: Sometimes, doctors prescribe it to help people lose weight when other methods haven't worked.
  • Bipolar Disorder: In some cases, it may be used to stabilize mood in people with bipolar disorder.

Dosage:

Monotherapy Of Generalised Tonic-clonic Seizures Or Focal Seizures With Or Without Secondary Generalization: 

  • Adult: Initially 25 Mg Once Daily At Night, For 1 Week, Then Increased In Steps Of 25-50 Mg Every 1-2 Weeks; Usual Dose 100-200 Mg Daily In 2 Divided Doses, Adjusted According To Response, Maximum 500 Mg Per Day; Doses Of 1 G Daily Have Been Used In Refractory Epilepsy 
  • Children 6-17 Yrs: Initially 0.5-1 Mg/kg Once Daily At Night, (max. Per Dose 25 Mg) For 1 Week, Then Increased In Steps Of 250-500 Mcg/kg Twice Daily, At Intervals Of 1-2 Weeks; Usual Dose 50 Mg Twice Daily (max. Per Dose 7.5 Mg/kg Twice Daily), If Child Cannot Tolerate Titration Then Smaller Steps Or Longer Interval Between Steps May Be Used; Maximum 500 Mg Per Day 

Adjunctive Treatment Of Generalised Tonic-clonic Seizures Or Focal Seizures With Or Without Secondary Generalization, Adjunctive Treatment For Seizures Associated With Lennox-gastaut Syndrome: 

  • Adult: Initially 25-50 Mg Once Daily At Night, For 1 Week, Then Increased In Steps Of 25-50 Mg Every 1-2 Weeks; Usual Dose 200-400 Mg Daily In 2 Divided Doses; Maximum 400 Mg Per Day 
  • Children 2-17 Yrs: Initially 1-3 Mg/kg Once Daily At Night, (max. Per Dose 25 Mg) For 1 Week, Then Increased In Steps Of 0.5-1.5 Mg/kg Twice Daily, Dose To Be Increased By A Maximum Of 25 Mg Twice Daily At Intervals Of 1-2 Weeks; Usual Dose 2.5-4.5 Mg/kg Twice Daily (max. Per Dose 7.5 Mg/kg Twice Daily), If Child Cannot Tolerate Then Smaller Steps Or Longer Interval Between Steps May Be Used; Maximum 400 Mg Per Day 

Migraine Prophylaxis: 

  • Adult: Initially 25 Mg Once Daily At Night, For 1 Week, Then Increased In Steps Of 25 Mg Every Week; Usual Dose 50-100 Mg Daily In 2 Divided Doses; Maximum 200 Mg Per Day

Content

  • Tab 25mg /50mg /100mg /200mg: Topiramate 25mg /50mg /100mg /200mg.
  • Cap 15mg /25mg /50mg: Topiramate 15mg /25mg /50mg.

Pregnancy

Avoid Unless The Potential Benefit Outweighs The Risk.

Stability

  • Sulphamate

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Contraindicated, Avoid

Side Effects

  • Abdominal Pain
  • Aggression
  • Agitation
  • Alopecia
  • Anaemia
  • Anxiety
  • Appetite Changes
  • Arthralgia
  • Cognitive Impairment
  • Confusion
  • Constipation
  • Depression
  • Diarrhoea
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Dyspepsia
  • Dyspnea
  • Epistaxis
  • Gastritis
  • Impaired Attention And Coordination
  • Irritability
  • Malaise
  • Movement Disorders
  • Muscle Spasm
  • Muscular Weakness
  • Myalgia
  • Nausea
  • Nephrolithiasis
  • Nystagmus
  • Paraesthesia
  • Pruritus
  • Rash
  • Seizures
  • Sleep Disturbance
  • Speech Disorder
  • Taste Disturbance
  • Tinnitus
  • Tremor
  • Urinary Disorders
  • Visual Disturbances
  • Vomiting

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