Topotecan

Therapeutic Group

Anti-neoplastics

Indication Dosage

Topotecan is a medication used to treat certain types of cancer, specifically ovarian cancer and small-cell lung cancer. It is prescribed by healthcare professionals as part of chemotherapy regimens to inhibit the growth and spread of cancer cells. Topotecan works by interfering with the replication of DNA in cancer cells, ultimately slowing down or halting their proliferation. 

Metastatic Ovarian Cancer When First-line Or Subsequent Treatment Has Failed, Treatment Of Recurrent Carcinoma Of The Cervix After Radiotherapy And For Patients With Stage Ivb Disease (in Combination With Cisplatin): 

By IV Infusion: 

  • Adults: 1-5mg/m2 Daily By IV Infusion Over 30 Min For 5 Consecutive Days. Repeat Every 3 weeks for a Minimum of 4 courses. 

Relapsed Small-cell Lung Cancer When Retreatment With The First-line Regimen Is Considered Inappropriate: 

By IV Infusion: 

  • Adult: (consult Product Literature Or Local Protocols)

Content

  • Inj Topotecan 4mg: Powder In Vial.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Topoisomerase 1 Inhibitor

Contra Indications

  • Severe Myelosuppression.

Precautions

  • Severe Myelosuppression.

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Anorexia
  • Asthenia
  • Bone Marrow Suppression
  • Extravasation
  • Gi Effects
  • Hyperuricaemia
  • Myelosuppression (dose Limiting)
  • Nausea
  • Oral Mucositis
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting.

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