Trastuzumab Emtansine

Therapeutic Group

Anti-neoplastics

Indication Dosage

Trastuzumab emtansine, commonly known as T-DM1, is a medication indicated for the treatment of HER2-positive breast cancer. It is prescribed for patients who have previously received trastuzumab (Herceptin) and a taxane chemotherapy, either separately or in combination, and whose cancer has progressed despite these treatments. T-DM1 works by targeting HER2 receptors on cancer cells, delivering a potent chemotherapy drug directly to the tumor, thereby inhibiting cancer cell growth and reducing the spread of the disease.

Monotherapy For The Treatment Of Her2-positive, Unresectable, Locally Advanced Or Metastatic Breast Cancer, In Adult Patients Who Have Previously Received Trastuzumab Separately Or In Combination, Or Who Have Developed Disease Recurrence During Or Within 6 Months Of Completing Adjuvant Therapy: 

By IV Infusion: 

  • Adults: 4mg/kg Iv Over 90 Mins. Maintenance: 2mg/kg IV over 30 Min Every Week.

Content

  • Inf 440mg: Per 20 ml
  • Trastuzumab 440mg.
  • Inf 160mg: Trastuzumab 160mg.
  • Inf 100mg: Trastuzumab 100mg.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Monoclonal Antibody

Contra Indications

  • Hypersensitivity To Murine Proteins, Severe Dyspnoea.

Precautions

  • Hypersensitivity To Murine Proteins, Severe Dyspnoea.

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Arthralgia
  • blurred Vision
  • Chills
  • Conjunctivitis
  • Dysgeusia
  • Gi Upset
  • Dyspepsia
  • Dyspnea
  • Epistaxis
  • Gingival Bleeding
  • Haemorrhage
  • Hand-foot Syndrome
  • hypertension
  • Hypokalaemia
  • Increased Lacrimation
  • Left Ventricular Dysfunction
  • Malaise
  • Memory Impairment
  • Myalgia
  • Nail Disorder
  • Peripheral Neuropathy
  • Peripheral Oedema
  • Pruritus
  • Pyrexia
  • Rash
  • Thrombocytopenia
  • Urinary Tract Infection
  • Urticaria
  • Hepatic Failure
  • Hepatic Toxicity
  • Interstitial Lung Disease
  • Nodular Regenerative Hyperplasia
  • Pneumonitis
  • alopecia
  • Bone-marrow Suppression
  • Extravasation
  • Hyperuricaemia
  • Oral Mucositis
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting