Kanjinti
Generic Name
Trastuzumab Emtansine
Packs Price
Company
Amgen
Therapeutic Group
Anti-neoplastics
Indication Dosage
Trastuzumab emtansine, commonly known as T-DM1, is a medication indicated for the treatment of HER2-positive breast cancer. It is prescribed for patients who have previously received trastuzumab (Herceptin) and a taxane chemotherapy, either separately or in combination, and whose cancer has progressed despite these treatments. T-DM1 works by targeting HER2 receptors on cancer cells, delivering a potent chemotherapy drug directly to the tumor, thereby inhibiting cancer cell growth and reducing the spread of the disease.
Monotherapy For The Treatment Of Her2-positive, Unresectable, Locally Advanced Or Metastatic Breast Cancer, In Adult Patients Who Have Previously Received Trastuzumab Separately Or In Combination, Or Who Have Developed Disease Recurrence During Or Within 6 Months Of Completing Adjuvant Therapy:
By IV Infusion:
- Adults: 4mg/kg Iv Over 90 Mins. Maintenance: 2mg/kg IV over 30 Min Every Week.
Content
- Inf 440mg: Per 20 ml
- Trastuzumab 440mg.
- Inf 160mg: Trastuzumab 160mg.
- Inf 100mg: Trastuzumab 100mg.
Pregnancy
Positive Evidence Of Risk: Avoid
Stability
Contra Indications
- Hypersensitivity To Murine Proteins, Severe Dyspnoea.
Precautions
- Hypersensitivity To Murine Proteins, Severe Dyspnoea.
Lactation
- Contraindicated. Discontinue Breast-feeding
Side Effects
- Arthralgia
- blurred Vision
- Chills
- Conjunctivitis
- Dysgeusia
- Gi Upset
- Dyspepsia
- Dyspnea
- Epistaxis
- Gingival Bleeding
- Haemorrhage
- Hand-foot Syndrome
- hypertension
- Hypokalaemia
- Increased Lacrimation
- Left Ventricular Dysfunction
- Malaise
- Memory Impairment
- Myalgia
- Nail Disorder
- Peripheral Neuropathy
- Peripheral Oedema
- Pruritus
- Pyrexia
- Rash
- Thrombocytopenia
- Urinary Tract Infection
- Urticaria
- Hepatic Failure
- Hepatic Toxicity
- Interstitial Lung Disease
- Nodular Regenerative Hyperplasia
- Pneumonitis
- alopecia
- Bone-marrow Suppression
- Extravasation
- Hyperuricaemia
- Oral Mucositis
- Thromboembolism
- Tumourlysis Syndrome
- Vomiting