Valsartan And Sacubitril
Therapeutic Group
Angiotensin-ii Antagonists, CombinationsIndication Dosage
Symptomatic Chronic Heart Failure With Reduced Ejection Fraction (patient Not Taking An Ace Inhibitor Or Angiotensin Ii Receptor Antagonist, Or Stabilised On Low Doses Of Any Of These Agents):
- Adult: Initially 26/24 Mg Twice Daily For 3-4 Weeks, Increased If Tolerated To 51/49 Mg Twice Daily For 3-4 Weeks, Then Increased If Tolerated To 103/97 Mg Twice Daily
Symptomatic Chronic Heart Failure With Reduced Ejection Fraction (patient Stabilised On An Ace Inhibitor Or Angiotensin Ii Receptor Antagonist):
- Adult: Initially 51/49 Mg Twice Daily For 2-4 Weeks, Increased If Tolerated To 103/97 Mg Twice Daily, Consider A Starting Dose Of 26/24 Mg If Systolic Blood Pressure Less Than 110mmhg
Content
- Tab 24 /26mg: Sacubitril 24mg /valsartan 26mg,
- Tab 49 /51mg: Sacubitril 49mg /valsartan 51mg,
- Tab 97 /103mg: Sacubitril 97mg /valsartan 103mg
Pregnancy
Contraindicated In Pregnancy.
Stability
- Angiotensin II Receptor Antagonists
Contra Indications
- Severe Hepatic Impairment, Concomitant Use Of Ace Inhibitor; Separate Administration By 36 Hours, Systolic Blood Pressure Less Than 100 Mmhg
Precautions
- Severe Hepatic Impairment, Concomitant Use Of Ace Inhibitor; Separate Administration By 36 Hours, Systolic Blood Pressure Less Than 100 Mmhg
Lactation
- Caution Advised
Side Effects
- Anaemia
- Diarrhoea
- Gastritis
- Hypoglycaemia
- Hypokalaemia
- Nausea
- Vertigo Hypersensitivity Reactions
- Renal Impairment