Symptomatic Chronic Heart Failure With Reduced Ejection Fraction (patient Not Taking An Ace Inhibitor Or Angiotensin Ii Receptor Antagonist, Or Stabilised On Low Doses Of Any Of These Agents):
Adult: Initially 26/24 Mg Twice Daily For 3-4 Weeks, Increased If Tolerated To 51/49 Mg Twice Daily For 3-4 Weeks, Then Increased If Tolerated To 103/97 Mg Twice Daily
Symptomatic Chronic Heart Failure With Reduced Ejection Fraction (patient Stabilised On An Ace Inhibitor Or Angiotensin Ii Receptor Antagonist):
Adult: Initially 51/49 Mg Twice Daily For 2-4 Weeks, Increased If Tolerated To 103/97 Mg Twice Daily, Consider A Starting Dose Of 26/24 Mg If Systolic Blood Pressure Less Than 110mmhg
Content
Tab 24 /26mg: Sacubitril 24mg /valsartan 26mg,
Tab 49 /51mg: Sacubitril 49mg /valsartan 51mg,
Tab 97 /103mg: Sacubitril 97mg /valsartan 103mg
Pregnancy
Contraindicated In Pregnancy.
Stability
Angiotensin II Receptor Antagonists
Contra Indications
Severe Hepatic Impairment, Concomitant Use Of Ace Inhibitor; Separate Administration By 36 Hours, Systolic Blood Pressure Less Than 100 Mmhg
Precautions
Severe Hepatic Impairment, Concomitant Use Of Ace Inhibitor; Separate Administration By 36 Hours, Systolic Blood Pressure Less Than 100 Mmhg