Vinblastine Sulfate

Therapeutic Group

Anti-neoplastics

Indication Dosage

Vinblastine Sulfate is a medication primarily indicated for the treatment of various types of cancer, including Hodgkin's disease, non-Hodgkin's lymphoma, testicular cancer, and Kaposi's sarcoma. It is commonly used as part of combination chemotherapy regimens to inhibit the growth and spread of cancer cells. Vinblastine Sulfate works by disrupting the microtubule structures within the cells, thereby preventing their ability to divide and multiply. This medication is typically administered by healthcare professionals through intravenous infusion and plays a crucial role in the management of cancer, offering hope to patients in their battle against this formidable disease.

Hodgkin's Disease, Lymphocytic Lymphoma, Histiocytic Lymphoma, Advanced Mycosis Fungoides, Advanced Testicular Cancer, Kaposi's Sarcoma, Letterersiwe Disease, Resistant Choriocarcinoma, Unresponsive Breast Cancer: 

By IV Inj Or Infusion: 

  • Adults: At Weekly Intervals:1st Dose=3.7 Mg/m2, 2nd Dose=5.5 Mg/m2, 3rd Dose=7.4 Mg/m2, 4th Dose=9.25 Mg/m2, 5th Dose= 11.1 Mg/m2, Increase To A Max 18.5 Mg/m2. 
  • Children: At Weekly Intervals: 1st Dose=2.5 Mg/ Rn2, 2nd Dose=3.75 Mg/m2, 3rd Dose=5 Mg/m2, 4th Dose=6.25 Mg/m2, 5th Dose= 7.5 Mg/m2, Increase To A Max 12.5 Mg/m2.

Content

  • Inj 10mg: Vinblastine Sulphate 10mg; Vial.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Vinca Alkaloid

Contra Indications

  • Bone Marrow Suppression.

Precautions

  • Bone Marrow Suppression.

Lactation

  • Contraindicated. Discontinue Breast-feeding

Side Effects

  • Alopecia
  • Autonomic Neuropathy
  • Hyperuricaemia
  • Loss Of Deep Tendon Reflexes
  • Motor Weakness
  • Myelosuppression(dose-limiting)
  • Nausea Neurotoxicity
  • Oral Mucositis
  • Ototoxicity
  • Peripheral Neuropathy
  • Peripheral Paraesthesia
  • Severe Bronchospasm Following Administration
  • Severe Local Irritation
  • Thromboembolism
  • Tumourlysis Syndrome
  • Vomiting