Therapeutic Group

Indication Dosage

Invasive Aspergillosis, Serious Infections Caused By Scedosporium Spp., Fusarium Spp., Or Invasive Fluconazole-resistant Candida Spp. (including C. Krusei): 

Oral: 

• Adult (body-weight Up To 40 Kg): Initially 200 Mg Every 12 Hours For 2 Doses, Then 100 Mg Every 12 Hours, Increased If Necessary To 150 Mg Every 12 Hours; 
• Adult (body weight 40 Kg And Above): Initially 400 Mg Every 12 Hours For 2 Doses, Then 200 Mg Every 12 Hours, Increased If Necessary To 300 Mg Every 12 Hours. Tab Should Be Taken 1 Hr Before Or 1 Hr After Food; Susp Should Be Taken 1 Hr Before Or 2 Hr After Food. 
• Children 2-12 Yrs: 9 Mg/kg Twice Daily (preferred As Susp < 12 Yr), Increase If Necessary In 1 Mg/kg Increments (50 Mg Increments If Initial Dose Was 350 Mg); Max 350 Mg Twice Daily; 
• 12-14 Yr And Body Wt < 50 Kg: Same As Adults. Tab Should Be Taken 1 Hr Before Or 1 Hr After Food; Susp Should Be Taken 1 Hr Before Or 2 Hr After Food. 

By IV Infusion: 

• Adult: Initially 6 Mg/kg Every 12 Hours For 2 Doses, Then 4 Mg/kg Every 12 Hours; Reduced If Not Tolerated To 3 Mg/kg Every 12 Hours; For Max 6 Months 
• Children 2-14 Yrs: And Less Than 50 Kg, Loading Dose: For First Hrs, 9 Mg/kg By Iv Inf Every 12 Hrs. Maintenance; 8 Mg/kg By IV Inf Twice Daily.
• Above 14 Yrs: Same As Adults. If the Response is Inadequate, the Maintenance Dose May Be Increased In 1 Mg/kg Steps. If Not Tolerated, It May Be Reduced To 1 Mg/kg Steps. Max Inf. Rate 3 Mg/kg/hr Over 1-3 Hr.

Content

Pregnancy

Caution Advised, Avoid

Stability

Contra Indications

Precautions

Lactation

Side Effects