Therapeutic Group

Indication Dosage

Severe Acute Ulcerative Colitis Refractory To Corticosteroid Treatment: 

By IV Infusion: 

• Adult: 2 Mg/kg, To Be Given Over 24 Hours, Dose Adjusted According To Blood-ciclosporin Concentration And Response 

Severe Active Rheumatoid Arthritis When Conventional Second-line Therapy Inappropriate Or Ineffective: 

• Adult: Initially 2.5 Mg/kg Daily In 2 Divided Doses, Increased Gradually If Necessary Up To 4 Mg/kg Daily After6 Weeks, Discontinue If Response Insufficient After 3 Months, Dose Adjusted According To Response For Maintenance And Treatment Reviewed After 6 Months 

Short-term Treatment Of Severe Atopic Dermatitis Where Conventional Therapy Ineffective Or Inappropriate, Severe Psoriasis Where Conventional Therapy Ineffective Or Inappropriate: 

• Adult: Initially 1.25 Mg/kg Twice Daily (max. Per Dose2.5 Mg/kg Twice Daily) Usual Maximum Duration Of8 Weeks But May Be Used For Longer Under Specialist Supervision, Discontinue If Inadequate Response After 3 Months At The Optimum Dose; Max Duration Of Treatment Usually 1 Year 

Organ Transplantation (used Alone): 

• Adult: 10-15 Mg/kg, To Be Administered 4-12 Hours Before Transplantation, Followed By 10-15 Mg/kg Daily For 1-2 Weeks Postoperatively, Then Maintenance2-6 Mg/kg Daily, Reduce Dose Gradually To Maintenance. Dose Should Be Adjusted According To Blood-ciclosporin Concentration And Renal Function; Dose Is Lower If Given Concomitantly With Other Immunosuppressant Therapy (e.g. Corticosteroids) 

Bone-marrow Transplantation, Prevention And Treatment Of Graft-versus-host Disease: 

By IV Infusion: 

• Adult: 3-5 Mg/kg Daily, To Be Administered Over 2-6 Hours From the Day Before Transplantation To 2 Weeks Postoperatively, Alternatively; Oral, Initially12.5-15 Mg/kg Daily, Then 12.5 Mg/kg Daily For 3-6 Months And Then Tailed Off (may Take Up To A Year After Transplantation) 

Nephrotic Syndrome: 

• Adult: 5 Mg/kg Daily In 2 Divided Doses, For Maintenance, Reduce To Lowest Effective Dose According To Proteinuria And Serum Creatinine Measurements; Discontinue After 3 Months If No Improvement In Glomerulonephritis Or Glomerulosclerosis (after 6 Months In Membranous Glomerulonephritis)

Content

Pregnancy

Consult with Doctor Or Caution Advised

Stability

Contra Indications

Precautions

Lactation

Side Effects