Sandimmun
Generic Name
Ciclosporin (cyclosporin)
Packs Price
- Inj 250 mg(008008): 10 Ampx5 ml: 6402.52: 7532.38
- Neoral Cap 100 mg(014962): 50: 8415.00: 9900.00
- Neoral Cap 25 mg (014963): 50: 2465.00: 2900.00
- Neoral Soln 100 mg/ml (014961): 50 ml: 5967.71: 7017.31 Sol 100mg/ml: 1: 7565.00: 8900.00
Company
Novartis
Therapeutic Group
Immunosuppressants
Indication Dosage
Severe Acute Ulcerative Colitis Refractory To Corticosteroid Treatment:
By IV Infusion:
- Adult: 2 Mg/kg, To Be Given Over 24 Hours, Dose Adjusted According To Blood-ciclosporin Concentration And Response
Severe Active Rheumatoid Arthritis When Conventional Second-line Therapy Inappropriate Or Ineffective:
- Adult: Initially 2.5 Mg/kg Daily In 2 Divided Doses, Increased Gradually If Necessary Up To 4 Mg/kg Daily After6 Weeks, Discontinue If Response Insufficient After 3 Months, Dose Adjusted According To Response For Maintenance And Treatment Reviewed After 6 Months
Short-term Treatment Of Severe Atopic Dermatitis Where Conventional Therapy Ineffective Or Inappropriate, Severe Psoriasis Where Conventional Therapy Ineffective Or Inappropriate:
- Adult: Initially 1.25 Mg/kg Twice Daily (max. Per Dose2.5 Mg/kg Twice Daily) Usual Maximum Duration Of8 Weeks But May Be Used For Longer Under Specialist Supervision, Discontinue If Inadequate Response After 3 Months At The Optimum Dose; Max Duration Of Treatment Usually 1 Year
Organ Transplantation (used Alone):
- Adult: 10-15 Mg/kg, To Be Administered 4-12 Hours Before Transplantation, Followed By 10-15 Mg/kg Daily For 1-2 Weeks Postoperatively, Then Maintenance2-6 Mg/kg Daily, Reduce Dose Gradually To Maintenance. Dose Should Be Adjusted According To Blood-ciclosporin Concentration And Renal Function; Dose Is Lower If Given Concomitantly With Other Immunosuppressant Therapy (e.g. Corticosteroids)
Bone-marrow Transplantation, Prevention And Treatment Of Graft-versus-host Disease:
By IV Infusion:
- Adult: 3-5 Mg/kg Daily, To Be Administered Over 2-6 Hours From the Day Before Transplantation To 2 Weeks Postoperatively, Alternatively; Oral, Initially12.5-15 Mg/kg Daily, Then 12.5 Mg/kg Daily For 3-6 Months And Then Tailed Off (may Take Up To A Year After Transplantation)
Nephrotic Syndrome:
- Adult: 5 Mg/kg Daily In 2 Divided Doses, For Maintenance, Reduce To Lowest Effective Dose According To Proteinuria And Serum Creatinine Measurements; Discontinue After 3 Months If No Improvement In Glomerulonephritis Or Glomerulosclerosis (after 6 Months In Membranous Glomerulonephritis)
Content
- Cap 25mg /50mg /100mg: cyclosporin 25mg /50mg /100mg,
- Inj 250mg: Cyclosporin 250mg
Pregnancy
Consult with Doctor Or Caution Advised
Stability
- Immunosuppressant
- Lymphokines Inhibitor
Contra Indications
- Pregnancy, Lactation. In Non-transplant Indications: Abnormal Baseline Renal Function, Malignancy, Uncontrolled Hypertension And Uncontrolled Infections
Precautions
- Pregnancy, Lactation. In Non-transplant Indications: Abnormal Baseline Renal Function, Malignancy, Uncontrolled Hypertension And Uncontrolled Infections
Lactation
- Consult with Doctor Or Caution Advised
Side Effects
- Acne
- Anorexia
- Convulsion
- Fatigue
- Flushing
- Gingival Hyperplasia
- Headache
- Hepatic Dysfunction
- Hirsutism
- Hyperglycaemia
- Hyperkalaemia
- Hyperlipidaemia
- Hypertension
- Hypertrichosis
- Hyperuricaemia
- Hypomagnesaemia
- Leucopenia
- Muscle Cramps
- Myalgia
- Gi Upset
- Paraesthesia
- Peptic Ulcer
- Pyrexia
- Renal Dysfunction (renal Structural Changes On Long-term Administration)
- Tremor
- Anaemia
- Oedema
- Signs Of Encephalopathy
- Thrombocytopenia
- Weight Gain
- Gynaecomastia
- Haemolytic Uraemic Syndrome
- Menstrual Disturbances
- Micro-angiopathic Haemolytic Anaemia
- Motor Polyneuropathy
- Muscle Weakness
- Myopathy
- Pancreatitis
- Visual Disturbances.
- Rare: Secondary To Benign Intracranial Hypertension
- Lymphoproliferative Disorder