Alone Or In Combination With Methotrexate To Treat; Severe And Progressive Rheumatoid Arthritis, Active Polyarticular-course Juvenile Idiopathic Arthritis, Active And Progressive Psoriatic Arthritis, Refractory To Puva Or Dmards Including Methotrexate, Severe Active Anylosingspondylitis:
By Sc Inj:
Adults: 25 Mg Twice Weekly Or 50 Mg Once Weekly
Children 4-18 Yr: 0.4 Mg/kg Twice Weekly Dose Interval Should Be 3-4 Days; Max 25 Mg Per Dose.
Chronic Severe Plaque Psoriasis Where Other Therapies Are Inappropriate:
By Sc Inj:
Adults: 25 Mg Twice Weekly Or 50 Mg Once Weekly. Alternatively, 50 Mg Twice Weekly For Up To 12 Weeks Then, If Necessary, 25 Mg Twice Weekly Or 50 Mg Once Weekly. Continue Treatment Until Remission; Max Up To 24 Weeks Unless Longer Treatment Is Appropriate. Discontinue If No Response After 12 Weeks. Re-treatment, 25 Mg Twice Weeklyor 50 Mg Once Weekly For Up To 24 Weeks
Children 8-18 Yrs: 0.8 Mg/kg (up To Max 50 Mg) Once Weekly For Up To 24 Weeks; Discontinue If No Response After 12 Weeks; Re-treatment, 0.8 Mg/kg (up To Max 50 Mg) Once Weekly For Up To 24 Wk.
Sepsis Or Risk Of Sepsis, Active Infection, Active Or Recurrent Gi Bleeding Or Ulceration, Cerebrovascular Disease, History Of Gi Bleeding Or Gi Perforation Related To Previous Nsaid Therapy, History Of Recurrent Gi Haemorrhage, Ischaemic Heart Disease, Heart Failure, Peripheral Arterial Disease, Moderate To Severe Renal Impairment Ensure Adequate Contraception.
Precautions
Sepsis Or Risk Of Sepsis, Active Infection, Active Or Recurrent Gi Bleeding Or Ulceration, Cerebrovascular Disease, History Of Gi Bleeding Or Gi Perforation Related To Previous Nsaid Therapy, History Of Recurrent Gi Haemorrhage, Ischaemic Heart Disease, Heart Failure, Peripheral Arterial Disease, Moderate To Severe Renal Impairment Ensure Adequate Contraception.
Lactation
Contraindicated or Not Recommended.
Side Effects
Injection Site Reactions
Infection
Headache
Ab-dominal Pain
Gi Disturbance
Pruritus
Fever
Allergic Reactions; If Serious
Discontinue Immediately
Reports Of Malignancies
Cardiovascular Symptoms
Cholecystitis
Pancreatitis
Gi Haemorrhage
Bursitis
Depression
Dyspnoea
Seizures
Angioedema
Interstitial Lung Disease
Cns Demyelinating Disorders Including Multiple Sclerosis And Optic Neuritis