Generic Name
Glibenclamide And MetforminPacks Price
- Tab 1.25/250 mg(030010): 2x15: 49.06: 57.72
- Tab 2.5/500 mg(030009): 2x15: 87.62: 103.09
- Tab 5/500 mg(030008): 2x15: 99.29: 116.82
Glucovance
Therapeutic Group
Blood Glucose Lowering Drugs, Excluding InsulinIndication Dosage
Glibenclamide and Metformin are medications used together to help control blood sugar levels in people with type 2 diabetes. They work by helping your body use insulin better and reducing the amount of sugar produced by your liver. This can help you manage your diabetes and keep your blood sugar within a healthy range.
Therapy for Type 2 Diabetes Mellitus:
- Adults: 250 Mg/1.25 Mg Once Daily. Patients With Fasting Glucose > 200 Mg/dl; May Start With 250 Mg/1.25 Mg Twice Daily. Dosage May Be Increased In Increments Of 250 Mg/1.25 Mg At Intervals Of Not Less Than 2 Wk; the Max Daily Dose is 2000 Mg/10 Mg.
Type 2 Diabetes Previously Treated With A Sulphonylureas Or Metformin Alone:
- Initial: 500 Mg/2.5 Mg Or 500 Mg/5 Mg Twice Daily, Can Be Increased In Increments. Maxdaily Dose 2000 Mg/20 Mg.
- Children: Not Recommended.
Content
- Tab 1.25 /250mg: Glibenclamide 1.25mg, Metformin Hci 250mg.
- Tab 2.5 /500mg: Glibenclamide 2.5mg, Metformin Hci 500mg.
- Tab 5 /500mg: Glibenclamide 5mg, Metformin Hci 500mg.
- Tab 2.5 /400
Pregnancy
Risk Cannot Be Ruled Out.
Stability
- Biguanide
- Sulphonylurea
Contra Indications
- Renal Dysfunction, Congestive Heart Failure, Acute Diabetic Ketoacidosis, Metabolic Acidosis, Diabetic Coma, Suspend Therapy During Surgery & Clinical Investigations Using Iv-iodinated Contrast Media.
Precautions
- Renal Dysfunction, Congestive Heart Failure, Acute Diabetic Ketoacidosis, Metabolic Acidosis, Diabetic Coma, Suspend Therapy During Surgery & Clinical Investigations Using Iv-iodinated Contrast Media.
Lactation
- Contraindicated or Not Recommended.
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal Pain
- Loss Of Appetite
- Crises Of Hepatic Porphyria & Porphyria Cutanea
- Elevations Of Se-rum Urea &creatinine Conc. Transie
- nt Visual Disturbances
- Leukopenia
- Thrombocytopenia
- Pruritus Urticaria
- Maculopapular Rash.
- Rare: Agranulocytosis
- Haemolyticanaemia
- Bone Marrow Aplasia & Pancytopenia
- Lactic Acidosis
- Liver Function Test Abnor-mality Or Hepatitis Requiring Withdrawals Of Treatment
- Cutaneous Or Visceral Allergic Angiitis
- Erythema Multiforme
- Exfoliative Dermatitis
- Photo-sensitization
- Urticaria Evolving To Shock & Cross-sensitivity To Sulphonamides.
Available Brands
Author
Shahid Arif