Adult: Initially 20 Mg/hour, Then Increased If Necessary To 40 Mg/hour After 30 Minutes, Then Increased If Necessary To 80 Mg/hour After 30 Minutes, Then Increased If Necessary To 160 Mg/hour After 30 Minutes, Adjusted According To Response; Usual Maximum 160 Mg/hour
Oral:
Adult: Use Dose For Hypertension
Hypertension Following Myocardial Infarction:
By IV Infusion:
Adult: 15 Mg/hour, Then Increased To Up To120 Mg/hour, Dose To Be Increased Gradually
Hypertensive Emergencies:
By IV Inj:
Adult: 50 Mg, Given Over At Least 1 Minute, Then 50 Mg Every 5 Minutes If Required Until A Satisfactory Response Occurs; Maximum 200 Mg Per Course
By IV Infusion:
Adult: Initially 2 Mg/minute Until A Satisfactory Response Is Achieved, Then Discontinue; Usual Dose 50-200 Mg
Hypertension:
Adult: Initially 100 Mg Twice Daily, Increased At Intervals Of 14 Days; Usual Dose 200 Mg Twice Daily, Increased If Necessary Up To 800 Mg Daily In 2 Divided Doses, To Be Taken With Food, Higher Doses To Be Given In 3-4 Divided Doses; Max 2.4 G Per Day
Elderly: Initially 50 Mg Twice Daily, Increased At Intervals Of 14 Days; Usual Dose 200 Mg Twice Daily, Increased If Necessary Up To 800 Mg Daily In 2 Divided Doses, To Be Taken With Food, Higher Doses To Be Given In 3-4 Divided Doses; Max 2.4 G Per Day
By IV Inj:
Adult: 50 Mg, Dose To Be Given Over At Least 1 Minute, Then 50 Mg After 5 Minutes If Required; Maximum 200 Mg Per Course
By IV Infusion:
Adult: Initially 2 Mg/minute Until A Satisfactory Response Is Achieved, Then Discontinue; Usual Dose50-200 Mg
Children: Not Recommended.
Content
Inj: Per ml: Labetalol Hci 5mg; 10 ml (50mg), 20 ml (100mg) Amp.
Tab 100mg /200mg: Labetalol Hci 100mg /200mg.
Pregnancy
Avoid, Known To Be Harmful, Except Possibly In The First Trimester
Stability
Alpha
Beta-blocker
Contra Indications
2nd Or 3rd Degree Av Block (without Pacemaker, Severe Bradycardia, Sick Sinus Syndrome, Un-controlled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.
Precautions
2nd Or 3rd Degree Av Block (without Pacemaker, Severe Bradycardia, Sick Sinus Syndrome, Un-controlled Heart Failure, Cardiogenic Shock, Severe Peripheral Arterial Disease, Hypotension, Metabolic Acidosis, Untreated Pheochromocytoma, Severe Asthma Or Copd.