Therapeutic Group

Indication Dosage

Lamotrigine is a medication primarily used to treat seizures in people with epilepsy. It can also be prescribed to help manage mood swings in individuals with bipolar disorder.

Monotherapy Of Seizures: 

• Adult & Children Above 12 Yrs: Initially 25 Mg Once Daily For 14 Days, Increased To 50 Mg Once Daily For Further 14 Days, Then Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 100-200 Mg/day In 2 Divided Doses (up To 500 Mg/day). 

Adjunctive Therapy Of Seizures With Valproate: 

• Adult & Children Above 12 Yrs: Initially 25 Mg On Alternate Days For 14 Days Then 25 Mg Once Daily For Further 14 Days, Thereafter Increased By Max 50 Mg Every 7-14 Days; Usual Maintenance, 100-200 Mg/day In 2 Divided Doses. 
• Children 2-12 Yrs: Initially 150 Mcg/kg Once Daily For 14 Days (those Weighing Less Than 13 Kg May Receive 2 Mg On Alternate Days For First 14 Days) Then 300 Mcg/kg Once Daily For Further 14 Days, Thereafter Increased By Max Of 300 Mcg/ Kg Every 7-14 Days; Usual Maintenance 1-5 Mg/kg Daily In 1-2 Divided Doses, Max 200mg/day; 

Adjunctive Therapy Of Seizures With Enzyme Inducing Drugs And Without Valproate: 

• Adult & Children Above 12 Yrs: Initially 50 Mg Once Daily For 14 Days Then 50 Mg Twice Daily For a Further 14 Days, Thereafter Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 200-400 Mg/day In 2 Divided Doses (up To 700 Mg/ Day). 
• Children 2-12 Yrs: Initially 300 Mcg/kg Twice Daily For 14 Days, Then 600 Mcg/kg Twice Daily For Further 14 Days, Thereafter Increased By Max 1.2 Mg/kg Every 7-14 Days; Usual Maintenance 5-15 Mg/kg Daily In 1-2 Divided Doses, Max 400 Mg/day 

Adjunctive Therapy Of Seizures Without Enzyme Inducing Drugs And Without Valproate: 

• Adult & Children Above 12 Yrs: Initially 25 Mg Once Daily For 14 Days, Increased To 50 Mg Once Daily For Further 14 Days, Then Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 100-200mg/day In 2 Divided Doses. 
• Children 2-12 Yrs: Initially 300 Mcg/kg, Daily In 1-2 Divided Doses For 14 Days, Then 600 Mcg/kg Daily In 1-2 Divided Doses For Further 14 Days, Thereafter Increased By Max 600 Mcg/kg Every 7-14 Days; Usual Maintenance 1-10 Mg/kg Daily In 1-2 Divided Doses; Max 200 Mg Daily 

Monotherapy Or Adjunctive Therapy Of Bipolar Disorder Without Enzyme Inducing Drugs Without Valproate: 

• Adult: Initially 25 Mg Once Daily For 14 Days, Then 50 Mg Daily In 1-2 Divided Doses For Further 14 Days, Then 100 Mg Daily In 1-2 Divided Doses For Further 7 Days: Usual Maintenance 200 Mg/day In 2 Divided Doses; Max 400 Mg/day. 

Adjunctive Therapy Of Bipolar Disorder With Valproate: 

• Adult & Children Above 12 Yrs: Initially 25 Mg On Alternate Days For 14 Days, Then 25 Mg Once Daily For Further 14 Days, Then 50 Mg Daily In 2 Divided Doses For Further 7 Days; Usual Maintenance 100 Mg Daily In 1-2 Divided Doses: Max 200 Mg Daily. 

Adjunctive Therapy Of Bipolar Disorder With Enzyme-Inducing Drugs Without Valproate: 

• Adult & Children Above 12 Yrs: Initially 50 Mg Once Daily For 14 Days, Then 50 Mg Twice Daily For a Further 14 Days, Then 100 Mg Twice Daily For a Further 7 Days, Then 150 Mg Twice Daily For a Further 7 Days; Usual Maintenance 200 Mg Twice Daily. 

Monotherapy Of Typical Absence Seizures: 

• Children 2-12 Yrs: Initially 300 Mcg/kg Daily In 1-2 Divided Doses For 14 Days, Then 600 Mcg/kg Daily In 1-2 Divided Doses For Further 14 Days, Thereafter Increased By Max 600 Mcg/kg Every 7-14 Days; Usual Maintenance 1-10 Mg/kg Daily In 1-2 Divided Doses (up To 15 Mg/kg Daily Has Been Required).

Content

Pregnancy

Avoid Unless The Potential Benefit Outweighs The Risk.

Stability

Contra Indications

Precautions

Lactation

Side Effects