Lamictal
Generic Name
Lamotrigine
Packs Price
- Tab 100 mg (014921): 30: 1611.85: 1896.29
- Tab 25 mg (014918): 30: 568.50: 668.82
- Tab 50 mg (014919): 30: 948.59: 1115.99
Company
GSK
Therapeutic Group
Anti-epileptics
Indication Dosage
Lamotrigine is a medication primarily used to treat seizures in people with epilepsy. It can also be prescribed to help manage mood swings in individuals with bipolar disorder.
Monotherapy Of Seizures:
- Adult & Children Above 12 Yrs: Initially 25 Mg Once Daily For 14 Days, Increased To 50 Mg Once Daily For Further 14 Days, Then Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 100-200 Mg/day In 2 Divided Doses (up To 500 Mg/day).
Adjunctive Therapy Of Seizures With Valproate:
- Adult & Children Above 12 Yrs: Initially 25 Mg On Alternate Days For 14 Days Then 25 Mg Once Daily For Further 14 Days, Thereafter Increased By Max 50 Mg Every 7-14 Days; Usual Maintenance, 100-200 Mg/day In 2 Divided Doses.
- Children 2-12 Yrs: Initially 150 Mcg/kg Once Daily For 14 Days (those Weighing Less Than 13 Kg May Receive 2 Mg On Alternate Days For First 14 Days) Then 300 Mcg/kg Once Daily For Further 14 Days, Thereafter Increased By Max Of 300 Mcg/ Kg Every 7-14 Days; Usual Maintenance 1-5 Mg/kg Daily In 1-2 Divided Doses, Max 200mg/day;
Adjunctive Therapy Of Seizures With Enzyme Inducing Drugs And Without Valproate:
- Adult & Children Above 12 Yrs: Initially 50 Mg Once Daily For 14 Days Then 50 Mg Twice Daily For a Further 14 Days, Thereafter Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 200-400 Mg/day In 2 Divided Doses (up To 700 Mg/ Day).
- Children 2-12 Yrs: Initially 300 Mcg/kg Twice Daily For 14 Days, Then 600 Mcg/kg Twice Daily For Further 14 Days, Thereafter Increased By Max 1.2 Mg/kg Every 7-14 Days; Usual Maintenance 5-15 Mg/kg Daily In 1-2 Divided Doses, Max 400 Mg/day
Adjunctive Therapy Of Seizures Without Enzyme Inducing Drugs And Without Valproate:
- Adult & Children Above 12 Yrs: Initially 25 Mg Once Daily For 14 Days, Increased To 50 Mg Once Daily For Further 14 Days, Then Increased By Max 100 Mg Every 7-14 Days; Usual Maintenance 100-200mg/day In 2 Divided Doses.
- Children 2-12 Yrs: Initially 300 Mcg/kg, Daily In 1-2 Divided Doses For 14 Days, Then 600 Mcg/kg Daily In 1-2 Divided Doses For Further 14 Days, Thereafter Increased By Max 600 Mcg/kg Every 7-14 Days; Usual Maintenance 1-10 Mg/kg Daily In 1-2 Divided Doses; Max 200 Mg Daily
Monotherapy Or Adjunctive Therapy Of Bipolar Disorder Without Enzyme Inducing Drugs Without Valproate:
- Adult: Initially 25 Mg Once Daily For 14 Days, Then 50 Mg Daily In 1-2 Divided Doses For Further 14 Days, Then 100 Mg Daily In 1-2 Divided Doses For Further 7 Days: Usual Maintenance 200 Mg/day In 2 Divided Doses; Max 400 Mg/day.
Adjunctive Therapy Of Bipolar Disorder With Valproate:
- Adult & Children Above 12 Yrs: Initially 25 Mg On Alternate Days For 14 Days, Then 25 Mg Once Daily For Further 14 Days, Then 50 Mg Daily In 2 Divided Doses For Further 7 Days; Usual Maintenance 100 Mg Daily In 1-2 Divided Doses: Max 200 Mg Daily.
Adjunctive Therapy Of Bipolar Disorder With Enzyme-Inducing Drugs Without Valproate:
- Adult & Children Above 12 Yrs: Initially 50 Mg Once Daily For 14 Days, Then 50 Mg Twice Daily For a Further 14 Days, Then 100 Mg Twice Daily For a Further 7 Days, Then 150 Mg Twice Daily For a Further 7 Days; Usual Maintenance 200 Mg Twice Daily.
Monotherapy Of Typical Absence Seizures:
- Children 2-12 Yrs: Initially 300 Mcg/kg Daily In 1-2 Divided Doses For 14 Days, Then 600 Mcg/kg Daily In 1-2 Divided Doses For Further 14 Days, Thereafter Increased By Max 600 Mcg/kg Every 7-14 Days; Usual Maintenance 1-10 Mg/kg Daily In 1-2 Divided Doses (up To 15 Mg/kg Daily Has Been Required).
Content
- Tab 2mg /5mg /25mg /50mg /100mg /200mg: Lamotrigine 2mg /5mg / 25mg /50mg /100mg /200mg.
Pregnancy
Avoid Unless The Potential Benefit Outweighs The Risk.
Stability
Contra Indications
- Significant Hepatic Impairment.
Precautions
- Significant Hepatic Impairment.
Lactation
Side Effects
- Aggression
- Agitation
- Arthralgia
- Ataxia
- Back Pain
- Blurred Vision
- Diarrhoea
- Diplopia
- Dizziness
- Drowsiness
- Dry Mouth
- Headache
- Insomnia
- Nausea
- Nystagmus
- Rash
- Tremor
- Vomiting
- Aseptic Meningitis
- Suicidal Ideation
- Skin Reactions Including Stevens-johnson Syndrome And Toxic Epidermal Necrolysis.
- Rare: Hallucination
- Conjunctivitis
- Anaemia
- Blood Disorders
- Confusion
- Exacerbation Of Parkinson's Disease
- Hepatic Failure
- Hypersensitivity Syndrome
- Leucopenia
- Lupus Erythematosus-like Reactions
- Movement Disorders
- Pancytopenia
- Thrombocytopenia
- Unsteadiness