Maturity-Onset Diabetes Mellitus, Monotherapy And In Combination With Insulin Or With Sulphonylureas Monotherapy:
Adults: Initially 500 -850 Mg Two Or Three Times Daily During Or After Meals, Adjust Dose According To Response By Increasing 500 Mg Or 850 Mg After 10-15 Days; Max Dose 3g Daily.
With Insulin:
Adults: Initially 500 Mg Daily, Increase 500 Mg Every Wk. Max: 2500 Mg/day. Decrease Insulin Dose 10-25% When Fasting Plasma Glucose Is Less Than the Desired Level.
Children Above 10yrs: Initially 500 -850 Mg Once Daily During Or After Meals As Mono Therapy Or With Insulin, Adjust Dose After 10-15 Days According To Blood Glucose Level; Max Dose 2g Daily In 2-3 Divided Dose.
Acute Metabolic Acidosis Or Pre-coma, Hepatic Or Severe Renal (gfr<30ml/min) Impairment. Acute Conditions Predisposing To Renal Impairment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs).
Precautions
Acute Metabolic Acidosis Or Pre-coma, Hepatic Or Severe Renal (gfr<30ml/min) Impairment. Acute Conditions Predisposing To Renal Impairment, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs).