Generic Name
LeflunomidePacks Price
- Tab 10 mg(047390): 30: 401.20: 472.50
- Tab 20 mg(047391): 30: 535.50: 630.00
Rhulef
Therapeutic Group
Anti-inflammatory And Anti-rheumatic ProductsIndication Dosage
Moderate To Severe Active Rheumatoid Arthritis, Active Psoriatic Arthritis:
- Adult: Initially 100 Mg Once Daily For 3 Days Then Reduced To 10-20 Mg Once Daily; If Dose Not Tolerated Or Alt Level Elevations; Reduce Dose To 10 Mg/day. If Elevations Persist Or Alt Level Is Higher Further, Discontinue.
- Children: Not Recommended.
Content
- Tab 10mg /20mg /100mg: Leflunomide 10mg /20mg /100mg.
Pregnancy
Contraindicated In Pregnancy
Stability
- Antimetabolite; Dmard (disease Modifying Antirheumatic Drugs)
Contra Indications
- Severe Immunodeficiency, Bone Marrow Dysfunction, Blood Dyscrasias, Serious Infections, Hepatic Impairment, Moderate To Severe Renal Insufficiency, Severe Hypoproteinaemia, Ulcerative Stomatitis. Contraception Must Be Used By Men And Women During And For 2 Years After Use Or Until Plasma Levels Fall Below 0.02 Mg/i.
Precautions
- Severe Immunodeficiency, Bone Marrow Dysfunction, Blood Dyscrasias, Serious Infections, Hepatic Impairment, Moderate To Severe Renal Insufficiency, Severe Hypoproteinaemia, Ulcerative Stomatitis. Contraception Must Be Used By Men And Women During And For 2 Years After Use Or Until Plasma Levels Fall Below 0.02 Mg/i.
Lactation
- Contraindicated or Not Recommended
Side Effects
- Abdominal Pain
- Alopecia
- Anorexia
- Asthenia
- Diarrhoea
- Dizziness
- Dry Skin
- Headache
- Increased Blood Pressure
- Leucopenia
- Nausea
- Oral Mucosal Disorders
- Paraesthesia
- Pruritus
- Rash
- Tenosynovitis
- Vomiting
- Anaemia
- Anxiety
- Hyperlipidaemia
- Hypokalaemia
- Hypophosphataemia
- Taste Disturbance
- Tendon Rupture
- Thrombocytopenia.
- Rare: Severe Hepatotoxicity
- Hepatitis
- Eosinophilia
- Interstitial Lung Disease
- Jaundice
- Pancytopenia
- Severe Infection
- Bone-marrow Toxicity
- Hypouricaemia
- Malignancy
- Reduced Sperm Count
- Renal Failure
- Pancreatitis
Author
Shahid Arif