Synjardy XR
Therapeutic Group
Blood Glucose Lowering Drugs, Excluding Insulin
Indication Dosage
Empagliflozin and Metformin HCl are medications used together to help lower blood sugar levels in adults with type 2 diabetes. They work by improving the way your body uses insulin and removing excess sugar from your bloodstream, helping you manage your diabetes better.
Type 2 Diabetes Mellitus Not Controlled By Metformin Alone Or By Metformin In Combination With Other Antidiabetic Drugs Or Insulin
Dosage:
- Adult 18-84 Years: 5/850-5/1000 Mg Twice Daily, Increased If Necessary To 12.5/850-12.5/1000 Mg Twice Daily
- Adult 85 Years And Over: Initiation Not Recommended
Content
- Tab 5mg /1000mg: Empagliflozin 5mg And Metformin Hci 1000mg,
- Tab 12.5mg /500mg: Empagliflozin 12.5mg And Metformin Hci 500mg,
- Tab 12.5mg /1000mg: Empagliflozin 12.5mg And Metformin Hci 1000mg
Pregnancy
Advised To Avoid
Stability
- Sodium Glucose Co-transporter 2 Inhibitors (sglt2)
- Biguanide
Contra Indications
- Diabetic Ketoacidosis, Severe Hepatic Impairment, Severe Renal Impairment, Acute Conditions Predisposing To Renal Impairment, Acute Metabolic Acidosis Or Pre-coma, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs)
Precautions
- Diabetic Ketoacidosis, Severe Hepatic Impairment, Severe Renal Impairment, Acute Conditions Predisposing To Renal Impairment, Acute Metabolic Acidosis Or Pre-coma, Cardiac Or Respiratory Failure, Recent Mi, Alcoholism, Pregnancy, Lactation, And Elderly (above 75yrs)
Lactation
Side Effects
- Genital Infection
- Hypoglycaemia (in Combination With Insulin Or Sulfonylurea)
- Polyuria
- Pruritus
- Urinary Tract Infection
- Dysuria
- Volume Depletion (rare). Reports Of Altered Lfts
- Hepatitis
- Gi Upset
- Taste Disturbance
- Skin Reactions
- Reduced B12 Absorptions
- Abnormal Liver Function Tests
- Rarely Lactic Acidosis