Generic Name
PazopanibPacks Price
- Tab 200 mg(084161): 30: 58.616.49: 468.960.57
- Tab 400 mg(084162): 30: 97.693.78: 114.933.86
Votrient
Therapeutic Group
Anti-neoplasticsIndication Dosage
Pazopanib is a medication used to treat advanced renal cell carcinoma (a type of kidney cancer) and soft tissue sarcoma (a rare cancer that affects the soft tissues of the body). It works by inhibiting the growth of cancer cells and the development of blood vessels that supply them. Pazopanib may be prescribed by healthcare professionals when other treatments have not been effective or as a first-line therapy for these specific types of cancer.
First-line Treatment Of Advanced Renal Cell Carcinoma, Treatment Of Advanced Renal Cell Carcinoma In Patients Who Have Had Previous Treatment With Cytokine Therapy:
- Adult: 800 Mg Daily, Adjust Dose In Steps Of 200mg According To Tolerability; Maximum 800 Mg Per Day
Treatment Of Selective Subtypes Of Advanced Soft-tissue Sarcoma:
- Adult: (consult Product Literature)
- Children: Not Recommended.
Content
- Tab 200mg /400mg: Pazopanib (as Hydrochloride) 200mg /400mg.
Pregnancy
Contraindication In Pregnancy
Stability
- Protein Kinase Inhibitor
Contra Indications
- Severe Hepatic Impairment, Cerebral Or Clinically Significant Haemorrhage Or Haemoptysis In The Past 6 Months.
Precautions
- Severe Hepatic Impairment, Cerebral Or Clinically Significant Haemorrhage Or Haemoptysis In The Past 6 Months.
Lactation
- Contraindicated. Discontinue Breast-feeding
Side Effects
- Abdominal Distension & Pain
- anorexia
- Blood Disorders
- Blurred Vision
- Chest Pain
- Dyspepsia
- Dyspnea
- Epistaxis
- Flushing
- Gi Upset
- Hepatic Dysfunction
- Hyperalbuminaemia
- Hyperbilirubinaemia
- Hypertension
- Hypothyroidism
- Increased Amylase
- Malaise
- Muscle Spasm
- Myalgia
- Nail Disorders
- Oedema
- Paraesthesia
- Pneumothorax
- Proteinuria (discontinue If Grade 4)
- Skin& Hair Discoloration
- Thrombocytopenia
- Venous Thromboembolic Events
- Alopecia
- Bone-marrow Suppression
- Hyperuricaemia
- Nausea
- Oral Mucositis
- Thromboembolism
- Tumourlysis Syndrome
- Vomiting.rare: Arthralgia
- Bradycardia
- Cardiac Dysfunction
- Fistula
- Gi Perforation
- Haemorrhage
- Hepatic Failure
- Hypertensive Crisis
- Hypomagnesaemia
- Menstrual Disturbances
- Myocardial Infarction
- Myocardial Ischaemia
- Oropharyngeal Pain
- Pancreatitis
- Peripheral Neuropathy
- Peritonitis
- Photosensitivity
- Pulmonary Embolism
- Qt-interval Prolongation
- Stroke
- Transient Ischaemic Attack
- Thrombotic Microangiopathy
Author
Shahid Arif