Generic Name
TofacitinibPacks Price
- Tab 5mg: Rs. 124880
Xeljanz
Therapeutic Group
ImmunosuppressantsIndication Dosage
Indications (Uses):
- Rheumatoid Arthritis (RA) – For adults with moderate to severe RA.
- Psoriatic Arthritis (PsA) – Used with other arthritis medicines.
- Ulcerative Colitis (UC) – For moderate to severe cases.
- Juvenile Arthritis (JIA) – For children (≥2 years) with joint inflammation.
- Graft-Versus-Host Disease (GVHD) – Used in transplant-related conditions.
Dosage:
- RA & PsA: 5 mg twice daily or 11 mg once daily (extended-release).
- Ulcerative Colitis:
- Start: 10 mg twice daily (for 8 weeks).
- Then: 5 mg twice daily.
- Juvenile Arthritis (JIA): 5 mg twice daily (if weight is 40 kg or more).
- GVHD: 10 mg twice daily, then reduced as needed.
Content
- Tab 5mg: Tofacitinib Citrate 5mg
Pregnancy
Avoid
Stability
- Janus Kinase (JAK) Inhibitors
Contra Indications
- Tofacitinib should not be used by people with active infections like TB or serious viral and fungal infections. It is unsafe for those with severe liver disease, a history of blood clots, or heart problems. People with very low blood counts should also avoid it. Live vaccines should not be taken while using this medicine. It is not safe during pregnancy or breastfeeding, as it may harm the baby.
Precautions
- Tofacitinib should not be used by people with active infections like TB or serious viral and fungal infections. It is unsafe for those with severe liver disease, a history of blood clots, or heart problems. People with very low blood counts should also avoid it. Live vaccines should not be taken while using this medicine. It is not safe during pregnancy or breastfeeding, as it may harm the baby.
Lactation
- Avoid
Side Effects
- Headache
- Diarrhea
- Nausea
- High blood pressure
- Increased cholesterol levels
Available Brands
Author
Shahid Arif