Actinomycin D

Therapeutic Group

Anti-neoplastics

Indication Dosage

Actinomycin D is a medication used to treat certain types of cancer. It works by stopping the growth of cancer cells in the body.

Choriocarcinoma, Ovarian Teratoma, Wilms Tumour, Rhabdomyosarcoma, Testicular Teratoma, Ewing's Sarcoma, Neuroblastoma (adjunct): 

  • Adults: 2.5 Mg/m2 In Divided Doses, Over 1 Week, Repeated Every 2 Weeks Or 0.75-2 Mg/m2 Every 1-4 Weeks Or 400-600 Mg/m2/day For 5 Days, Repeated Every 3-6 Weeks. Refer To Individual Protocol.

Content

  • Inj: actinomycin D 0.5mg Per 3 ml Vial.

Pregnancy

Positive Evidence Of Risk: Avoid

Stability

  • Cytotoxic Antibiotic

Contra Indications

  • Patients With Concurrent Or Recent Chickenpox Or Herpes Zoster, Anaphylactic Reaction

Precautions

  • Patients With Concurrent Or Recent Chickenpox Or Herpes Zoster, Anaphylactic Reaction

Lactation

  • Contraindicated. Discontinue Breast Feeding

Side Effects

  • Radiosensitization Effects
  • Bone Marrow Suppression
  • Neutropenic Fever
  • Anaphylactic Reaction
  • Fatigue
  • Alopecia (reversible)
  • Stevens-johnson Syndrome
  • Growth Retardation
  • Hyperuricemia
  • Abdominal Pain
  • Anorexia
  • Diarrhoea
  • Gi Ulceration
  • Nausea
  • Vomiting
  • Anaemia
  • Increased Bilirubin
  • Hepatotoxicity
  • Liver Function Test Abnor-mality
  • Erythema Oedema
  • Myaliga.

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