Aliskiren
Therapeutic Group
Anti-hypertensiveIndication Dosage
Aliskiren is a medication primarily prescribed to manage hypertension (high blood pressure). It belongs to a class of drugs known as direct renin inhibitors and effectively works to lower blood pressure by inhibiting the activity of renin, an enzyme involved in regulating blood pressure. Aliskiren may be used alone or in combination with other antihypertensive medications when lifestyle changes alone are insufficient in controlling blood pressure.
Essential Hypertension Either Alone Or In Combination With Other Anti-hypertensives:
- Adult: 150 Mg Once Daily, Increased If Necessary To 300 Mg Once Daily
Content
- Tab 150mg /300mg: Aliskiren 150mg /300mg.
Pregnancy
Contraindicated In Pregnancy.
Stability
- Renin Inhibitor
Contra Indications
- Concomitant Treatment With An Ace Inhibitor Or An Angiotensin-ii Receptor Antagonist In Patients With An Egfr Less Than 60 Ml/minute/1.73m2, Concomitant Treatment With An Ace Inhibitor Or An Angiotensin-ii Receptor Antagonist In Patients With Diabetes Mellitus, Hereditary Angioedema, Idiopathic Angioedema
- Children: Not Recommended.
Precautions
- Concomitant Treatment With An Ace Inhibitor Or An Angiotensin-ii Receptor Antagonist In Patients With An Egfr Less Than 60 Ml/minute/1.73m2, Concomitant Treatment With An Ace Inhibitor Or An Angiotensin-ii Receptor Antagonist In Patients With Diabetes Mellitus, Hereditary Angioedema, Idiopathic Angioedema
- Children: Not Recommended.
Lactation
- Not Recommended.
Side Effects
- Arthralgia
- Dizziness
- Hyperkalaemia
- Diarrhoea
- Liver Disorders
- Nausea
- Vertigo
- Vomiting.
- Rare: Acute Renal Failure (reversible On Discontinuation Of Treatment)
- Hypotension
- Palpitation
- Peripheral Oedema
- Cough
- Pruritus
- Rash
- Stevens-johnson Syndrome
- Toxic Epidermal Necrolysis
- Urticaria
- Anaemia
- Angioedema
- Erythema.