Ampicillin

Therapeutic Group

Beta-Lactam Anti-bacterials, Penicillins

Indication Dosage

Susceptible Infections Including Bronchitis, urinary tract infections, Otitis Media, Sinusitis, Pneumonia, and Salmonellosis: 

Oral: 

  • Adult: 0.5-1 G Every 6 Hours 
  • Children 1-11 Months: 125 Mg 4 Times A Day; Increased If Necessary Up To 30 Mg/kg 4 Times A Day; 
  • 1-4 Yrs: 250 Mg 4 Times A Day; Increased If Necessary Up To 30 Mg/kg 4 Times A Day; 
  • 5-11 Yrs: 500 Mg 4 Times A Day; Increased If Necessary Up To 30 Mg/kg 4 Times A Day (max. Per Dose1 G); 
  • 12-17 Yrs: 500 Mg 4 Times A Day; Increased If necessary To 1 G 4 Times A Day, Use Increased Dose In severe Infection 

By IV or IM Inj, Or By IV Infusion: 

  • Adult: 500 Mg Every 4-6 Hours 

Endocarditis (in Combination With Another Antibiotic), Listerial Meningitis (in Combination With another Antibiotic): 

By IV Infusion: 

  • Adult: 2 G Every 4 Hours 

Lower & Upper Respiratory Tract Infections: 

  • Adults & Children Above 20 Kg Body Weight: 250 Mg Every 6 Hr. Less Than 20 Kg Body Weight: 50 Mg/kg/day Divided As 6 Hourly Or 8 Hourly Dose. 

By IV Or IM Inj: 

  • Adults: 250-500 Mg Four To Six Times Daily; 
  • Children: Half Adult Dose. 

Meningitis: 

By IV Inj: 

  • Adults & Children: 150-200 Mg/kg/day Given Every 3-4 Hr.

Content

  • Cap 250mg /500mg: Ampicillin (as Trihydrate) 250mg /500mg.
  • Drop Paed: Per 1.25 ml: Ampicillin (as Trihydrate) 125mg; Powder For Reconstitution.
  • Inj 250mg /500mg /1gm /2gm: Ampicillin

Pregnancy

Caution Advised

Stability

  • Penicillins

Contra Indications

  • History Of Flucloxacillin Associated Jaundice/hepatic Dysfunction, Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.

Precautions

  • History Of Flucloxacillin Associated Jaundice/hepatic Dysfunction, Hypersensitivity To Penicillins, Cephalosporins Or Other Beta-lactams.

Lactation

  • Caution Advised

Side Effects

  • Hypersensitivity Reaction
  • Gi Disturbance
  • Nausea And Vomiting. Rarely Hepatitis
  • Cholestatic Jaundice
  • Haematological And Cns Effects
  • Pseudomembranous Colitis
  • Increased Inr
  • Stevens-johnson's Syndrome
  • Toxic Epidermal Necrosis.

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