Esomeprazole And Sodium Bicarbonate

Therapeutic Group

Peptic Ulcer & Gastro-Oesophageal Reflux Disease

Indication Dosage

Reflux Oesophagitis: 

  • Adults: 20 Mg Once Daily For 4 Wk, Extend For A Further 4-8 Weeks If Not Fully Healed. 

Refractory Cases: 

  • Adults: 40 Mg Once Daily.

Acid-reflux Disease:

  • Adults: Long-term Management, 10 Mg Once Daily, Increased To 20 Mg Once Daily If Symptoms Return.

Benign Duodenal Ulceration:

  • Adults: 20 Mg Once Daily For 4 Weeks. Severe Cases; Increased To 40 Mg Once Daily.

Prevention Of Relapse:

  • Adults: 10 Mg Once Daily, Increasing To 20 Mg Once Daily If Symptoms Return.

Duodenal Ulceration With Helicobacter Pylori:

  • Adults: 40 Mg Daily With Amoxicillin 1.5-2 Gm Daily For 2 Weeks.

Benign Gastric Ulceration:

  • Adults: 20 Mg Once Daily For 8 Wk. Severe Cases: Increase To 40 Mg Once Daily.

Zollinger-Ellison Syndrome:

  • Adults: 60 Mg Once Daily Adjusted To Response.
  • Usual Maintenance: 20-120 Mg Daily. Doses Over 80 Mg Daily Are Given In Two Divided Doses

Acid Aspiration: 

  • Adults: 40 Mg In The Evening Of The Day Before Surgery, Then 40 Mg 1-4 hours prior To Surgery.
  • Children: Not Recommended.

Content

  • Cap 20 Mg/1100 mg: Esomeprazole 20 mg and Sodium Bicarbonate 1100 Mg.
  • Cap 40 Mg/1100 mg: Esomeprazole 40 mg And Sodium Bicarbonate 1100 mg.

Pregnancy

Risk Cannot Be Ruled Out.

Stability

  • Antacid
  • Proton Pumps Inhibitor (PPI)

Contra Indications

  • Known

Precautions

  • Known

Lactation

  • Not Recommended

Side Effects

  • Headache
  • Somnolence
  • Insomnia
  • Arthralgia
  • Gi Upset
  • Skin Rashes
  • Paraesthesia
  • Dizziness
  • Myalgia
  • Increased Risk Of Gi Infections
  • Increase In Liver Enzymes.

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