Fosfomycin

Therapeutic Group

Other Anti-Bacterial

Indication Dosage

Acute Uncomplicated Lower Urinary-tract Infections: 

Oral Sachet: 

  • Adult: 3 G Single-dose 1 Sachet, Mix With 3-4 Oz Of Water. Prophylaxis Of Urinary-tract

Infections In Transurethral Surgical Procedures: 

Oral Sachet: 

  • Adult: 3 G Single-dose 1 Sachet, Mix With 3-4 Oz Of Water, To Be Given 3 Hours Before Surgery. Dose Maybe Repeated Once, 24 Hours After Surgery 

Osteomyelitis, Hospital-acquired Lower Respiratory-tract Infections When First-line Treatments Are Inappropriate Or Ineffective: 

Oral: 

  • Adults: 500 Mg 6 Hourly. 
  • Children: 250 Mg 6 Hourly 

By IM Inj: 

  • Adult: 1 G 8 Hourly; 
  • Children: 500 Mg 8 Hourly 

By IV Infusion: 

  • Adult: 12-24 G Daily In 2-3 Divided Doses (max. Per Dose 8 G), Use The High-dose Regimen In Severe Infection Suspected Or Known To Be Caused By Less Sensitive Organisms 
  • Children: Half The Adult Dose; See Literature 

Complicated Urinary-tract Infections When First-line Treatment Ineffective Or Inappropriate: 

Oral: 

  • Adults: 500 Mg 6 Hourly. 
  • Children: 250 Mg 6 Hourly 

By IM Inj: 

  • Adult: 1 G 8 Hourly; 
  • Children: 500 Mg 8 Hourly 

By IV Infusion: 

  • Adult: 12-16 G Daily In 2-3 Divided Doses (max. Per Dose 8 G) 
  • Children: Half The Adult Dose; See Literature 

Bacterial Meningitis When First-line Treatment Ineffective Or Inappropriate: 

Oral: 

  • Adults: 500 Mg 6 Hourly. 
  • Children: 250 Mg 6 Hourly 

By IM Inj: 

  • Adult: 1 G 8 Hourly; 
  • Children: 500 Mg 8 Hourly 

By IV Infusion: 

  • Adult: 16-24 G Daily In 3-4 Divided Doses (max. Per Dose 8 G), Use The High-dose Regimen In Severe Infection Suspected Or Known To Be Caused By Less Sensitive Organisms 
  • Children: Half The Adult Dose; See Literature

Content

  • Cap 500mg: Fosfomycin 500mg.
  • Inj1gm IM /IV: Fosfomycin 1gm.
  • Susp 250mg /500mg: Per 5 ml: Fosfomycin 250mg /500mg.
  • Powder: Fosfomycin Trometamol 3gm.

Pregnancy

Use Only If Potential Benefit Outweighs Risk.

Stability

  • Antibiotic

Contra Indications

  • None Known

Precautions

  • None Known

Lactation

  • Contraindicated

Side Effects

  • Gi Disturbances
  • Diarrhoea
  • Nausea
  • Rash
  • Vomiting
  • Abdominal Pain
  • Antibiotic-associated Colitis
  • Dizziness
  • Headache
  • Decreased Appetite
  • Dyspnea
  • Fatigue
  • Hypernatraemia
  • Hypokalaemia
  • Taste Disturbances
  • Vertigo.
  • Rare: Aplastic Anaemia
  • Blood Disorders
  • Eosinophilia
  • Bronchospasm
  • Confusion
  • Hepatitis
  • Jaundice
  • Tachycardia

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