Heparin

Therapeutic Group

Anti-thrombotic Agents

Indication Dosage

Heparin is used to prevent and treat blood clots in the body. It's often prescribed to reduce the risk of strokes, heart attacks, and deep vein thrombosis (DVT) during surgery or certain medical conditions.

 

Treatment Of Pulmonary Embolism, Unstable Angina, and acute Peripheral Arterial Occlusion: 

By IV Inj:

Adult: Loading Dose Of 5000 Units Or 75 Units/kg Followed By Continuous IV Inj Of 18 Units/kg/hr.10000 Units In Severe Pulmonary Embolism, 

 

Treatment Of Deep-vein Thrombosis: 

By IV Or Sc Inj: 

  • Adult: Loading Dose Of 5000 Units Or 75 Units/kg, Followed By Continuous Iv Inf Of 18 Units/kg/hr Or By Sc Of 15000 Units Every 12 Hrs. 

 

Thromboprophylaxis: 

Adults By Sc Inj:

  • In Medical Patients: 5000 Units Every 8-12 Hrs.
  • In Surgical Patients: 5000 Units 2 Hrs Before Surgery, Then Every 8-12 Hrs. 
  • During Pregnancy: 5000-10000 Units Every 12 Hrs. 

Extracorporeal Circulation And Haemodialysis: 

By IV Inj: 

  • Adult: 1000-5000 Units, Followed By Continuous IV infusion Of 250-1000 Units/hr 
  • Children: Some Preparations Are Licensed For Use In Children. 

Maintenance Of Neonatal Umbilical Arterial Catheter: 

By IV Infusion: 

  • Neonate: 0.5 Units/hr 

Treatment Of Thrombotic Episodes: 

By IV Infusion: 

  • Neonate, 1 Month-1 Yr: Initially 75 Units/kg (50 Units/kg If Under 35 Wk Corrected Gestational Age) By IV Injection, Then By Continuous IV infusion 25 Units/kg/hr, Adjusted According To Aptt; 
  • 1-18 Yrs: Initially, 75 Units/kg By IV Injection, Then By Continuous IV infusion 20 units/kg/hr, Adjusted According To Aptt

By Sc Inj: 

  • 1 Month-18 Yrs: 250 Units/kg Twice Daily, Adjusted According To Aptt 

Prophylaxis Of Thrombotic Episodes:

By Sc Inj: 

  • 1 Month-18 yrs: 100 units/kg (max 5000 Units) Twice Daily, Adjusted According To Aptt. 
    Prevention Of Clotting In Extracorporeal Circuits And Maintenance Of Cardiac Shunts And Critical Stents: Consult Product Literature.

Content

  • Inj: Heparinsodium /calcium 1000 Units (1 ml) /5000 Units (1 ml) /25000 Units (1 ml) /10000units (2ml) /12500 Units (0.5 ml) /20000units (0.8 ml) /7500 Units (0.3 ml) Amp /via Pre-Filled Syringe. .

Pregnancy

Caution Advised; Maternal Osteoporosis Reported After Prolonged Use

Stability

  • Anticoagulant

Contra Indications

  • Haemorrhagic, Diathesis, Deficiency Of Coagulation Factors, Severe Hepatic, Renal Or Pancreatic Impairment, Severe Thrombocytopenia, Gi Ulcers, Hypertension, Brain Haemorrhage, Cos Injury Or Surgery, Cerebral Arterial Aneurysm, Retinopathy, Vitreous Haemorrhage, Ophthalmic Surgery, Subacute Bacterial Endocarditis, Imminent Abortion.

Precautions

  • Haemorrhagic, Diathesis, Deficiency Of Coagulation Factors, Severe Hepatic, Renal Or Pancreatic Impairment, Severe Thrombocytopenia, Gi Ulcers, Hypertension, Brain Haemorrhage, Cos Injury Or Surgery, Cerebral Arterial Aneurysm, Retinopathy, Vitreous Haemorrhage, Ophthalmic Surgery, Subacute Bacterial Endocarditis, Imminent Abortion.

Lactation

  • May Be Used in Breast Feeding

Side Effects

  • Bleeding Complications
  • Transient Alopecia
  • Thrombocytopenia; Osteoporosis (long-term Therapy)
  • Febrileor Allergic Reactions
  • Hypoaldosteronism
  • Reaction At Injection Site.

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