Prochlorperazine

Therapeutic Group

Anti-Emetic & Anti-Nauseants

Indication Dosage

Prochlorperazine is a medication that is primarily used to treat nausea and vomiting caused by various conditions, such as migraines, chemotherapy, and gastrointestinal disorders. It belongs to a class of drugs called phenothiazines, which work by blocking certain dopamine receptors in the brain. This medication can also be used to treat certain psychiatric conditions, such as schizophrenia and anxiety, but it is not typically the first-line treatment for these disorders.

Nausea And Vomiting, Acute Attack: 

Oral: 

  • Adult: Initially 20 Mg, Then 10 Mg After 2 Hours 

By Deep IM Inj: 

  • Adult: 12.5 Mg As Required, Followed By An Oral Dose After 6 Hours, if Necessary. 

Nausea And Vomiting, Prevention And Treatment: 

Oral: 

  • Adult: 5-10 Mg 2-3 Times A Day. 
  • Children 1-11 Years (body weight 10 Kg And Above): 250 Micrograms/kg 2-3 Times A Day.
  • Children 12-17 Years: 5-10 Mg Up To 3 Times A Day If Required. 

By Deep IM Inj: 

  • Adult: 12.5 Mg As Required, Followed By An Oral Dose After 6 Hours, If Necessary. 
  • Children 2-4 Years: 1.25-2.5 Mg Up To 3 Times A Day If Required; 
  • 5-11 Years: 5-6.25 Mg Up To 3 Times A Day If Required; 
  • 12-17 Years: 12.5 Mg Up To 3 Times A Day If Required 

Labyrinthine Disorders: 

Oral: 

  • Adult: 5 Mg 3 Times A Day, Increased If Necessary To 30 Mg Daily In Divided Doses, Increased Gradually, Then Reduced To 5-10 Mg Daily, Dose Is Reduced After Several Wks 

Nausea And Vomiting In Previously Diagnosed Migraine: 

Oral: 

  • Adult & Children 12 Yrs: 3-6 Mg Twice Daily. 

Schizophrenia And Other Psychoses, Mania: 

Oral: 

  • Adult: 12.5 Mg Twice Daily For 7 Days, Dose To Be Adjusted At Intervals Of 4-7 Days According To Response; Usual Dose 75-100 Mg Daily. 

By Deep IM Inj: 

  • Adult: 12.5-25 Mg 2-3 Times A Day. 

Short-term Adjunctive Management Of Severe Anxiety: 

Oral: 

  • Adult: 15-20 Mg Daily In Divided Doses; Maximum 40 Mg Per Day. Doses Are Expressed As Prochlorperazine Maleate Or Mesilate; 1mg Prochlorperazine Maleate: 1 Mg Prochlorperazine Mesilate.

Content

  • Inj: Per 1 ml Amp: ProchlorPerazine Mesilate 12. 5mg.
  • Tab 3mg /5mg: ProchlorPerazine Maleate 3mg /5mg.

Pregnancy

Caution Advised

Stability

  • Antihistamine

Contra Indications

  • Children Under 10 Kg Body Weight, Cns Depression, Comatose States, Phaeochromocytoma, Bone Marrow Depression, Liver Impairment.

Precautions

  • Children Under 10 Kg Body Weight, Cns Depression, Comatose States, Phaeochromocytoma, Bone Marrow Depression, Liver Impairment.

Lactation

  • Caution Advised

Side Effects

  • Impaired Judgment And Dexterity
  • Cns Disturbances
  • Acute Dys Tonic Reactions Such As Facial And Skeletal Muscle Spasms And Oculogyric Crises
  • Anticholinergic Effects
  • Ecg And Endocrine Changes
  • Allergic Effects And Extra-pyramidal Symptoms Occur Rarely At Low Dosage.

Available Brands