Sitagliptin

Therapeutic Group

Blood Glucose Lowering Drugs, Excluding Insulin

Indication Dosage

Type 2 Diabetes Mellitus As Monotherapy Or In Combination With Metformin Or A Sulfonylurea, Or Pioglitazone (duel Therapy), And In Combination With Both Metformin And A Sulfonylurea (triple Therapy) To Achieve Adequate Glycaemic Control: 

  • Adult: 100 Mg Once Daily 

Type 2 Diabetes Mellitus In Combination With Both Metformin And Pioglitazone, Or In Combination With Insulin (With or Without Metformin) When Insulin Alone Fails To Provide Adequate Glycaemic Control: 

  • Adult: 100 Mg Once Daily. The dose Of Concomitant Sulfonylurea Or Insulin May Need To Be Reduced. 
  • Children: Not Recommended.

Content

  • Tab 25mg /50mg /100mg: Sitagliptin 25mg /50mg /100mg (as Phosphate Monohydrate).

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Dipeptidyl Peptidase-4 Inhibitor

Contra Indications

  • Ketoacidosis, Severe Renal Impairment.

Precautions

  • Ketoacidosis, Severe Renal Impairment.

Lactation

  • Not Recommended.

Side Effects

  • Gi Disturbances
  • Nasopharyngitis
  • Pain
  • Peripheral Oedema
  • Upper Respiratory Tract Infection
  • Anorexia
  • Dizziness
  • Drowsiness
  • Dry Mouth
  • Headache
  • Hypoglycaemia
  • Cutaneous Vasculitis
  • Pancreatitis (discontinue) Rash
  • Stevens-johnson Syndrome
  • Osteoarthritis.

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