Sitagliptin And Metformin

Therapeutic Group

Blood Glucose Lowering Drugs, Excluding Insulin

Indication Dosage

Type 2 Diabetes Mellitus Not Controlled By Metformin Alone Or In Combination With Either A Sulfonylurea Or Pioglitazone Or Insulin:

  • Adult: Initially 1 Tablet50mg/500 Mg Or 50 Mg/1000 Mg Twice Daily. Doses Of Sulfonylurea Or Insulin May Need To Be Reduced. Max Daily Dose Of Sitagliptin 100 Mg. 
  • Children: Not Recommended.

Content

  • Tab 50mg /500mg: Sitagliptin (as Phosphate Monohydrate) 50mg, Metformin Hydrochloride 500mg.
  • Tab 50mg /850mg: Sitagliptin (as Phosphate Monohydrate) 50mg, Metformin Hydrochloride 850mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Biguanide
  • Dipeptidyl Peptidase-4 Inhibitor

Contra Indications

  • Renal Or Hepatic Impairment, Diabetic Ketoacidosis Or Pre-coma, Cardiac Or Respiratory Failure, Recent Mi, Acute Alcohol Intoxication, Alcoholism.

Precautions

  • Renal Or Hepatic Impairment, Diabetic Ketoacidosis Or Pre-coma, Cardiac Or Respiratory Failure, Recent Mi, Acute Alcohol Intoxication, Alcoholism.

Lactation

  • Not Recommended.

Side Effects

  • Serious Hyper Sensitivity Reactions Including Anaphylaxis And Stevens-johnson Syndrome (discontinue)
  • nausea
  • Lactic Acidosis (discontinue)
  • Hypoglycaemia
  • Constipation
  • Headache
  • Diarrhoea
  • Vomiting.

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