Rosiglitazone And Metformin

Therapeutic Group

Blood Glucose Lowering Drugs, Excluding Insulin

Indication Dosage

Type 2 Diabetes Not Controlled By Metformin Alone, Or In Triple Therapy With A Sulphonylureas: 

  • Adult: Initially 1 Tab Of 2 Mg/1000 Mg Tab, Twice Daily With Meals Or Right After Meals. Increase To 2 Tab Of 2 Mg/500 Mg Tab Or 1 Tab Of 4 Mg/1000 Mg Tab Twice Daily After 8 weeks if Greater Glycaemic Control Is Required. As Per Requirement, This Medicine May Be Used To Substitute Concomitant Rosiglitazone And Metformin In Existing Dual Or Triple Therapy. 
  • Children: Not Recommended.

Content

  • Tab 1 /500mg: Rosiglitazone (as Maleate) 1mg, Metformin Hydrochloride 500mg.
  • Tab 2 /500mg: Rosiglitazone (as Maleate) 2mg, Metformin Hydrochloride 500mg.
  • Tab 4 /500mg: Rosiglitazone (as Maleate) 4mg, Metformin Hydrochloride 500mg.

Pregnancy

Contraindicated In Pregnancy.

Stability

  • Biguanide
  • Thiazolidinedione

Contra Indications

  • Cardiac Failure Or History Of Cardiac Failure, Respiratory Failure, Recent Mi, Shock, Hepatic Impairment, Alcohol Intoxication, Alcoholism, Diabetic Ketoacidosis, Renal Impairment, Dehydration, Severe Infection, Acute Coronary Syndrome.

Precautions

  • Cardiac Failure Or History Of Cardiac Failure, Respiratory Failure, Recent Mi, Shock, Hepatic Impairment, Alcohol Intoxication, Alcoholism, Diabetic Ketoacidosis, Renal Impairment, Dehydration, Severe Infection, Acute Coronary Syndrome.

Lactation

  • Contraindicated or Not Recommended

Side Effects

  • Disturbances In Visual Acuity
  • Hepatic Impairment
  • Renal Impairment
  • Risk Of Fractures (especially In Women)
  • Ischaemic Heart Disease
  • Anaemia
  • Hypoglycaemia
  • Gi Upset
  • Dizziness
  • Weight Gain
  • Oedema.

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